功能： induction:Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide.,similarity:Belongs to the phosphatase and actin regulator family.,similarity:Contains 4 RPEL repeats.,subcellular location:Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.,subunit:Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.,tissue specificity:Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U937, GOTO and HL-60 leukemia cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus matrix. Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.
组织表达： Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.
功能： induction:Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide.,similarity:Belongs to the phosphatase and actin regulator family.,similarity:Contains 4 RPEL repeats.,subcellular location:Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.,subunit:Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.,tissue specificity:Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U937, GOTO and HL-60 leukemia cells.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus matrix. Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.
组织表达： Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.
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