功能： function:Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. ATR may stimulate the RAD9A dissociation.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the AAA ATPase family.,subunit:Interacts with RB1 predominantly in G1 phase via its LXCXE motif. Interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents.,
功能： function:Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. ATR may stimulate the RAD9A dissociation.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the AAA ATPase family.,subunit:Interacts with RB1 predominantly in G1 phase via its LXCXE motif. Interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents.,
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