功能： function:Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.,miscellaneous:Has no hydrolase activity as missing metal-binding sites in NUDIX motif.,PTM:Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.,similarity:Belongs to the Nudix hydrolase family. CPSF5 subfamily.,similarity:Contains 1 nudix hydrolase domain.,subcellular location:In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.,subunit:Homodimer. Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Interacts with CPSF6, PABPN1 and SNRNP70. Interacts with PAPOLA; the interaction is diminished by acteylation.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763). .
组织表达： Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
功能： function:Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.,miscellaneous:Has no hydrolase activity as missing metal-binding sites in NUDIX motif.,PTM:Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.,similarity:Belongs to the Nudix hydrolase family. CPSF5 subfamily.,similarity:Contains 1 nudix hydrolase domain.,subcellular location:In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.,subunit:Homodimer. Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Interacts with CPSF6, PABPN1 and SNRNP70. Interacts with PAPOLA; the interaction is diminished by acteylation.,
相关产品： RS0001,RS0002,YM3028,YM3029
细胞定位： Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763). .
组织表达： Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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