功能: regulation of cytokine-mediated signaling pathway, protein folding, response to unfolded protein, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, response to organic substance, negative regulation of macromolecule metabolic process, regulation of proteolysis, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, negative regulation of cellular catabolic process,regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of protein catabolic process, negative regulation of protein catabolic process,regulation of nitric oxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, negative regulation of proteolysis, positive regulation of nitrogen compound metabolic process, negative regulation of protein metabolic process, response to protein stimulus, regulation of interferon-gamma-mediated signaling pathway,regulation of type I interferon-mediated signaling pathway,
细胞定位: Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). .
功能: regulation of cytokine-mediated signaling pathway, protein folding, response to unfolded protein, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, response to organic substance, negative regulation of macromolecule metabolic process, regulation of proteolysis, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, negative regulation of cellular catabolic process,regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of protein catabolic process, negative regulation of protein catabolic process,regulation of nitric oxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, negative regulation of proteolysis, positive regulation of nitrogen compound metabolic process, negative regulation of protein metabolic process, response to protein stimulus, regulation of interferon-gamma-mediated signaling pathway,regulation of type I interferon-mediated signaling pathway,
细胞定位: Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). .