其他名称： Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain]
功能： cell fate determination, morphogenesis of an epithelium, morphogenesis of an epithelial sheet, immune system development, transcription, regulation of transcription, DNA-dependent, anti-apoptosis, induction of apoptosis, cell cycle, cell cycle arrest, cell surface receptor linked signal transduction, Notch signaling pathway, determination of left/right symmetry, pattern specification process, negative regulation of cell proliferation, regulation of cell size,response to wounding, determination of symmetry, determination of bilateral symmetry, positive regulation of signal transduction, positive regulation of cell communication, regulation of cell death, positive regulation of cell death,induction of programmed cell death, cell growth, stem cell maintenance, cell cycle process, hemopoiesis, embryonic limb morphogenesis, regeneration, regulation of cellular component size, appendage morphogenesis, limb morphogenesis, embryonic appendage morphogenesis, growth, wound healing, regulation of cell proliferation, tissue regeneration, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,cell fate commitment, regulation of transcription, negative regulation of cell differentiation, regulation of Ras protein signal transduction, positive regulation of Ras protein signal transduction, hemopoietic or lymphoid organ development, developmental growth, embryonic morphogenesis, tissue morphogenesis, appendage development,stem cell differentiation, stem cell development, regulation of small GTPase mediated signal transduction, positive regulation of small GTPase mediated signal transduction, regulation of RNA metabolic process, limb development,epithelium development, negative regulation of cell death,
相关产品： YC0070,YC0069,YC0068,KA3978C,KA3970C
细胞定位： [Notch 2 extracellular truncation]: Cell membrane ; Single-pass type I membrane protein .; [Notch 2 intracellular domain]: Nucleus . Cytoplasm . Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737). .
组织表达： Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
其他名称： Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain]
功能： cell fate determination, morphogenesis of an epithelium, morphogenesis of an epithelial sheet, immune system development, transcription, regulation of transcription, DNA-dependent, anti-apoptosis, induction of apoptosis, cell cycle, cell cycle arrest, cell surface receptor linked signal transduction, Notch signaling pathway, determination of left/right symmetry, pattern specification process, negative regulation of cell proliferation, regulation of cell size,response to wounding, determination of symmetry, determination of bilateral symmetry, positive regulation of signal transduction, positive regulation of cell communication, regulation of cell death, positive regulation of cell death,induction of programmed cell death, cell growth, stem cell maintenance, cell cycle process, hemopoiesis, embryonic limb morphogenesis, regeneration, regulation of cellular component size, appendage morphogenesis, limb morphogenesis, embryonic appendage morphogenesis, growth, wound healing, regulation of cell proliferation, tissue regeneration, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,cell fate commitment, regulation of transcription, negative regulation of cell differentiation, regulation of Ras protein signal transduction, positive regulation of Ras protein signal transduction, hemopoietic or lymphoid organ development, developmental growth, embryonic morphogenesis, tissue morphogenesis, appendage development,stem cell differentiation, stem cell development, regulation of small GTPase mediated signal transduction, positive regulation of small GTPase mediated signal transduction, regulation of RNA metabolic process, limb development,epithelium development, negative regulation of cell death,
相关产品： YC0070,YC0069,YC0068,KA3978C,KA3970C
细胞定位： [Notch 2 extracellular truncation]: Cell membrane ; Single-pass type I membrane protein .; [Notch 2 intracellular domain]: Nucleus . Cytoplasm . Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737). .
组织表达： Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
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