功能： circulatory system process, apoptosis, induction of apoptosis, activation of caspase activity, cell adhesion, cell surface receptor linked signal transduction, sensory perception, sensory perception of sound, blood circulation, cell death, cell proliferation, negative regulation of cell proliferation, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, response to organic substance, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death,death, negative regulation of angiogenesis, biological adhesion, response to monosaccharide stimulus, regulation of cell proliferation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity, regulation of caspase activity, positive regulation of molecular function, regulation of angiogenesis,neurological system process, cognition, sensory perception of mechanical stimulus, regulation of hydrolase activity,positive regulation of hydrolase activity, regulation of peptidase activity, regulation of endopeptidase activity,
相关产品： YT1026,YC0078,YC0051,KA3952C,KA3951C
细胞定位： Secreted, extracellular space, extracellular matrix, basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). .
组织表达： Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3. Isoform 1 and isoform 3 are expressed at low levels in artery, fat, pericardium and peripherical nerve, but not in placenta, mesangium, skin, pleura and cultured umbilical endothelial cells.
功能： circulatory system process, apoptosis, induction of apoptosis, activation of caspase activity, cell adhesion, cell surface receptor linked signal transduction, sensory perception, sensory perception of sound, blood circulation, cell death, cell proliferation, negative regulation of cell proliferation, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, response to organic substance, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death,death, negative regulation of angiogenesis, biological adhesion, response to monosaccharide stimulus, regulation of cell proliferation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity, regulation of caspase activity, positive regulation of molecular function, regulation of angiogenesis,neurological system process, cognition, sensory perception of mechanical stimulus, regulation of hydrolase activity,positive regulation of hydrolase activity, regulation of peptidase activity, regulation of endopeptidase activity,
相关产品： YT1026,YC0078,YC0051,KA3952C,KA3951C
细胞定位： Secreted, extracellular space, extracellular matrix, basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). .
组织表达： Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3. Isoform 1 and isoform 3 are expressed at low levels in artery, fat, pericardium and peripherical nerve, but not in placenta, mesangium, skin, pleura and cultured umbilical endothelial cells.
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