功能： protein import into nucleus, translocation, cell cycle checkpoint, DNA damage checkpoint, negative regulation of transcription from RNA polymerase II promoter, regulation of cell growth, in utero embryonic development, cell activation, release of cytochrome c from mitochondria, cell activation during immune response, lymphocyte activation during immune response, T cell activation during immune response, T cell proliferation during immune response, B cell lineage commitment, response to tumor cell, T cell lineage commitment, leukocyte activation during immune response,immune system development, leukocyte differentiation, DNA metabolic process, regulation of DNA replication, DNA repair, base-excision repair, nucleotide-excision repair, double-strand break repair, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,protein complex assembly, protein targeting, protein import into nucleus, mitochondrial transport, cellular ion homeostasis, regulation of pH, intracellular protein transport, nucleocytoplasmic transport, apoptosis, induction of apoptosis, activation of caspase activity, immune response, response to osmotic stress, response to DNA damage stimulus, ER overload response, ER-nuclear signaling pathway, mitochondrion organization, mitochondrial membrane organization, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, intracellular signaling cascade, regulation of mitotic cell cycle, gastrulation, negative regulation of neuroblast proliferation, aging, cell aging, protein localization,negative regulation of DNA replication, cell death, cell proliferation, negative regulation of cell proliferation, regulation of cell size, induction of apoptosis by intracellular signals, DNA damage response, signal transduction resulting in induction of apoptosis, activation of caspase activity by cytochrome c, apoptotic mitochondrial changes, cellular response to starvation, rRNA transcription, response to radiation, response to UV, response to light stimulus,response to abiotic stimulus, response to salt stress, embryonic development ending in birth or egg hatching,negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to extracellular stimulus, response to X-ray, response to ionizing radiation, response to gamma radiation, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, negative regulation of cell development, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death, protein transport, membrane organization, death, negative regulation of transcription, protein import, cellular homeostasis, cell cycle process,cellular cation homeostasis, cellular monovalent inorganic cation homeostasis, hemopoiesis, lymphocyte differentiation, B cell differentiation, T cell differentiation, negative regulation of cell growth, DNA damage response, signal transduction by p53 class mediator, regulation of cellular pH, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, DNA integrity checkpoint, G1 DNA damage checkpoint,G1/S transition checkpoint, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, regulation of cellular component size, regulation of gene-specific transcription, RNA biosynthetic process, mononuclear cell proliferation, T cell differentiation in the thymus, protein localization in organelle, cellular response to stress, protein localization in nucleus, cellular protein localization, cellular response to UV, response to endoplasmic reticulum stress, regulation of growth, T cell proliferation, T cell activation, B cell activation, regulation of cell proliferation, cellular response to glucose starvation, response to drug, homeostatic process, response to starvation, DNA damage response, signal transduction, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, regulation of apoptosis, chordate embryonic development, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, positive regulation of gene-specific transcription, positive regulation of caspase activity,regulation of caspase activity, regulation of neuron apoptosis, positive regulation of neuron apoptosis,macromolecular complex subunit organization, negative regulation of molecular function, positive regulation of molecular function, cell fate commitment, establishment of protein localization, leukocyte activation, regulation of transcription, negative regulation of cell differentiation, negative regulation of cell cycle, negative regulation of cell size, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent,negative regulation of growth, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, lymphocyte activation, lymphocyte proliferation, regulation of mitochondrial membrane permeability, intracellular transport,regulation of fibroblast proliferation, negative regulation of fibroblast proliferation, hemopoietic or lymphoid organ development, embryonic morphogenesis, chemical homeostasis, regulation of neurogenesis, negative regulation of neurogenesis, ion homeostasis, regulation of DNA metabolic process, negative regulation of DNA metabolic process,regulation of helicase activity, negative regulation of helicase activity, nuclear transport, nuclear import, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process,regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process, protein oligomerization, protein tetramerization, chromosome organization, regulation of hydrolase activity, positive regulation of hydrolase activity, negative regulation of hydrolase activity, regulation of intracellular pH, regulation of cell cycle, regulation of nervous system development, regulation of peptidase activity, regulation of endopeptidase activity, monovalent inorganic cation homeostasis, cation homeostasis, cellular chemical homeostasis,regulation of cell development, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis, leukocyte proliferation, cellular macromolecule localization,
细胞定位： Cytoplasm . Nucleus . Nucleus, PML body . Endoplasmic reticulum . Mitochondrion matrix . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). .; [Isoform 1]: Nucleus . Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; [Isoform 2]: Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 3]: Nucleus. Cytoplasm. Localized in the nucleus in most cells but found in the cytoplasm in some cells.; [Isoform 4]: Nucleus. Cytoplasm. Predominantly nuclear but translocates to the cytoplasm following cell stress.; [Isoform 7]: Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 8]: Nucleus. Cytoplasm. Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; [Isoform 9]: Cytoplasm.
组织表达： Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
功能： protein import into nucleus, translocation, cell cycle checkpoint, DNA damage checkpoint, negative regulation of transcription from RNA polymerase II promoter, regulation of cell growth, in utero embryonic development, cell activation, release of cytochrome c from mitochondria, cell activation during immune response, lymphocyte activation during immune response, T cell activation during immune response, T cell proliferation during immune response, B cell lineage commitment, response to tumor cell, T cell lineage commitment, leukocyte activation during immune response,immune system development, leukocyte differentiation, DNA metabolic process, regulation of DNA replication, DNA repair, base-excision repair, nucleotide-excision repair, double-strand break repair, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,protein complex assembly, protein targeting, protein import into nucleus, mitochondrial transport, cellular ion homeostasis, regulation of pH, intracellular protein transport, nucleocytoplasmic transport, apoptosis, induction of apoptosis, activation of caspase activity, immune response, response to osmotic stress, response to DNA damage stimulus, ER overload response, ER-nuclear signaling pathway, mitochondrion organization, mitochondrial membrane organization, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, intracellular signaling cascade, regulation of mitotic cell cycle, gastrulation, negative regulation of neuroblast proliferation, aging, cell aging, protein localization,negative regulation of DNA replication, cell death, cell proliferation, negative regulation of cell proliferation, regulation of cell size, induction of apoptosis by intracellular signals, DNA damage response, signal transduction resulting in induction of apoptosis, activation of caspase activity by cytochrome c, apoptotic mitochondrial changes, cellular response to starvation, rRNA transcription, response to radiation, response to UV, response to light stimulus,response to abiotic stimulus, response to salt stress, embryonic development ending in birth or egg hatching,negative regulation of biosynthetic process, positive regulation of biosynthetic process, response to extracellular stimulus, response to X-ray, response to ionizing radiation, response to gamma radiation, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, negative regulation of cell development, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death, protein transport, membrane organization, death, negative regulation of transcription, protein import, cellular homeostasis, cell cycle process,cellular cation homeostasis, cellular monovalent inorganic cation homeostasis, hemopoiesis, lymphocyte differentiation, B cell differentiation, T cell differentiation, negative regulation of cell growth, DNA damage response, signal transduction by p53 class mediator, regulation of cellular pH, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, DNA integrity checkpoint, G1 DNA damage checkpoint,G1/S transition checkpoint, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, regulation of cellular component size, regulation of gene-specific transcription, RNA biosynthetic process, mononuclear cell proliferation, T cell differentiation in the thymus, protein localization in organelle, cellular response to stress, protein localization in nucleus, cellular protein localization, cellular response to UV, response to endoplasmic reticulum stress, regulation of growth, T cell proliferation, T cell activation, B cell activation, regulation of cell proliferation, cellular response to glucose starvation, response to drug, homeostatic process, response to starvation, DNA damage response, signal transduction, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, regulation of apoptosis, chordate embryonic development, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, positive regulation of gene-specific transcription, positive regulation of caspase activity,regulation of caspase activity, regulation of neuron apoptosis, positive regulation of neuron apoptosis,macromolecular complex subunit organization, negative regulation of molecular function, positive regulation of molecular function, cell fate commitment, establishment of protein localization, leukocyte activation, regulation of transcription, negative regulation of cell differentiation, negative regulation of cell cycle, negative regulation of cell size, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent,negative regulation of growth, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, lymphocyte activation, lymphocyte proliferation, regulation of mitochondrial membrane permeability, intracellular transport,regulation of fibroblast proliferation, negative regulation of fibroblast proliferation, hemopoietic or lymphoid organ development, embryonic morphogenesis, chemical homeostasis, regulation of neurogenesis, negative regulation of neurogenesis, ion homeostasis, regulation of DNA metabolic process, negative regulation of DNA metabolic process,regulation of helicase activity, negative regulation of helicase activity, nuclear transport, nuclear import, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process,regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process, protein oligomerization, protein tetramerization, chromosome organization, regulation of hydrolase activity, positive regulation of hydrolase activity, negative regulation of hydrolase activity, regulation of intracellular pH, regulation of cell cycle, regulation of nervous system development, regulation of peptidase activity, regulation of endopeptidase activity, monovalent inorganic cation homeostasis, cation homeostasis, cellular chemical homeostasis,regulation of cell development, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis, leukocyte proliferation, cellular macromolecule localization,
细胞定位： Cytoplasm . Nucleus . Nucleus, PML body . Endoplasmic reticulum . Mitochondrion matrix . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recruited into PML bodies together with CHEK2 (PubMed:12810724). Translocates to mitochondria upon oxidative stress (PubMed:22726440). Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). .; [Isoform 1]: Nucleus . Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; [Isoform 2]: Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 3]: Nucleus. Cytoplasm. Localized in the nucleus in most cells but found in the cytoplasm in some cells.; [Isoform 4]: Nucleus. Cytoplasm. Predominantly nuclear but translocates to the cytoplasm following cell stress.; [Isoform 7]: Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm.; [Isoform 8]: Nucleus. Cytoplasm. Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; [Isoform 9]: Cytoplasm.
组织表达： Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
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