功能： protein import into nucleus, translocation, MAPKKK cascade, activation of MAPK activity, skeletal system development,ossification, response to hypoxia, in utero embryonic development, regulation of protein amino acid phosphorylation,positive regulation of protein amino acid phosphorylation, reproductive developmental process, detection of oxygen,regulation of DNA replication, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation, protein targeting, protein import into nucleus,phosphorus metabolic process, phosphate metabolic process, intracellular protein transport, nucleocytoplasmic transport, induction of apoptosis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, SMAD protein nuclear translocation, intracellular signaling cascade, protein kinase cascade, sensory organ development, salivary gland development, salivary gland morphogenesis, female pregnancy, aging, protein localization, negative regulation of DNA replication, negative regulation of cell proliferation,regulation of cell size, detection of chemical stimulus, response to wounding, response to endogenous stimulus,response to hormone stimulus, embryonic development ending in birth or egg hatching, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of signal transduction, response to organic substance, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, positive regulation of cell communication, negative regulation of cell communication, regulation of collagen metabolic process, positive regulation of collagen metabolic process, regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition, positive regulation of cell development, regulation of cell morphogenesis involved in differentiation, positive regulation of cell morphogenesis involved in differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation,regulation of cell death, positive regulation of cell death, induction of programmed cell death, protein transport, cell growth, phosphorylation, regulation of transforming growth factor beta receptor signaling pathway, protein import,regulation of phosphate metabolic process, menstrual cycle phase, ovulation cycle process, regulation of cell morphogenesis, gland morphogenesis, regulation of ossification, respiratory tube development, lung development,regulation of bone mineralization, positive regulation of bone mineralization, negative regulation of transforming growth factor beta receptor signaling pathway, mammary gland development, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of cell projection organization,positive regulation of cell projection organization, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of intracellular transport, positive regulation of intracellular transport, multicellular organism reproduction, regulation of cellular component size, response to progesterone stimulus, regulation of gene-specific transcription, regulation of protein localization, regulation of collagen biosynthetic process, positive regulation of collagen biosynthetic process, regulation of intracellular protein transport, regulation of protein import into nucleus, translocation, positive regulation of protein import into nucleus, translocation, protein localization in organelle, positive regulation of kinase activity, cell junction organization, response to fluid shear stress, protein localization in nucleus,cellular protein localization, response to laminar fluid shear stress, exocrine system development, tube development,growth, wound healing, regulation of cell proliferation, regulation of protein import into nucleus, regulation of phosphorylation, positive regulation of phosphorylation, odontogenesis, ovulation cycle, regulation of apoptosis,chordate embryonic development, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,positive regulation of catalytic activity, positive regulation of gene-specific transcription, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of neuron apoptosis, negative regulation of neuron apoptosis, regulation of kinase activity, ear development, response to estrogen stimulus, ossification involved in bone remodeling, regulation of cellular component biogenesis, positive regulation of molecular function, regulation of multicellular organismal metabolic process, positive regulation of multicellular organismal metabolic process,establishment of protein localization, cell-cell junction organization, regulation of transcription, positive regulation of cell differentiation, positive regulation of DNA replication, positive regulation of ossification, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of transcription, DNA-dependent,negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter,regulation of nucleocytoplasmic transport, bone remodeling, intracellular transport, lung alveolus development,rhythmic process, response to steroid hormone stimulus, embryonic organ morphogenesis, gut development,embryonic organ development, embryonic morphogenesis, reproductive process in a multicellular organism, embryonic cranial skeleton morphogenesis, embryonic neurocranium morphogenesis, embryonic skeletal system morphogenesis,skeletal system morphogenesis, embryonic skeletal system development, gland development, tissue remodeling, inner ear development, regulation of protein secretion, positive regulation of protein secretion, regulation of secretion,positive regulation of secretion, positive regulation of transport, regulation of DNA metabolic process, negative regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of developmental process, positive regulation of cellular component organization, nuclear transport, nuclear import,negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of protein transport, regulation of protein transport, positive regulation of multicellular organismal process, positive regulation of protein metabolic process,regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of cell division, regulation of transferase activity, positive regulation of transferase activity, regulation of filopodium assembly, positive regulation of filopodium assembly, detection of stimulus, positive regulation of cell division, palate development, regulation of cell development, regulation of cellular localization, bone development, bone morphogenesis, cranial suture morphogenesis, frontal suture morphogenesis, regulation of SMAD protein nuclear translocation, positive regulation of SMAD protein nuclear translocation, regulation of pathway-restricted SMAD protein phosphorylation, regulation of cell projection assembly, respiratory system development, negative regulation of cell death, regulation of biomineral formation, positive regulation of biomineral formation, regulation of establishment of protein localization, response to oxygen levels, detection of hypoxia, cellular macromolecule localization,
功能： protein import into nucleus, translocation, MAPKKK cascade, activation of MAPK activity, skeletal system development,ossification, response to hypoxia, in utero embryonic development, regulation of protein amino acid phosphorylation,positive regulation of protein amino acid phosphorylation, reproductive developmental process, detection of oxygen,regulation of DNA replication, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation, protein targeting, protein import into nucleus,phosphorus metabolic process, phosphate metabolic process, intracellular protein transport, nucleocytoplasmic transport, induction of apoptosis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, SMAD protein nuclear translocation, intracellular signaling cascade, protein kinase cascade, sensory organ development, salivary gland development, salivary gland morphogenesis, female pregnancy, aging, protein localization, negative regulation of DNA replication, negative regulation of cell proliferation,regulation of cell size, detection of chemical stimulus, response to wounding, response to endogenous stimulus,response to hormone stimulus, embryonic development ending in birth or egg hatching, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of signal transduction, response to organic substance, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, positive regulation of cell communication, negative regulation of cell communication, regulation of collagen metabolic process, positive regulation of collagen metabolic process, regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition, positive regulation of cell development, regulation of cell morphogenesis involved in differentiation, positive regulation of cell morphogenesis involved in differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation,regulation of cell death, positive regulation of cell death, induction of programmed cell death, protein transport, cell growth, phosphorylation, regulation of transforming growth factor beta receptor signaling pathway, protein import,regulation of phosphate metabolic process, menstrual cycle phase, ovulation cycle process, regulation of cell morphogenesis, gland morphogenesis, regulation of ossification, respiratory tube development, lung development,regulation of bone mineralization, positive regulation of bone mineralization, negative regulation of transforming growth factor beta receptor signaling pathway, mammary gland development, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of cell projection organization,positive regulation of cell projection organization, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of intracellular transport, positive regulation of intracellular transport, multicellular organism reproduction, regulation of cellular component size, response to progesterone stimulus, regulation of gene-specific transcription, regulation of protein localization, regulation of collagen biosynthetic process, positive regulation of collagen biosynthetic process, regulation of intracellular protein transport, regulation of protein import into nucleus, translocation, positive regulation of protein import into nucleus, translocation, protein localization in organelle, positive regulation of kinase activity, cell junction organization, response to fluid shear stress, protein localization in nucleus,cellular protein localization, response to laminar fluid shear stress, exocrine system development, tube development,growth, wound healing, regulation of cell proliferation, regulation of protein import into nucleus, regulation of phosphorylation, positive regulation of phosphorylation, odontogenesis, ovulation cycle, regulation of apoptosis,chordate embryonic development, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,positive regulation of catalytic activity, positive regulation of gene-specific transcription, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of neuron apoptosis, negative regulation of neuron apoptosis, regulation of kinase activity, ear development, response to estrogen stimulus, ossification involved in bone remodeling, regulation of cellular component biogenesis, positive regulation of molecular function, regulation of multicellular organismal metabolic process, positive regulation of multicellular organismal metabolic process,establishment of protein localization, cell-cell junction organization, regulation of transcription, positive regulation of cell differentiation, positive regulation of DNA replication, positive regulation of ossification, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of transcription, DNA-dependent,negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter,regulation of nucleocytoplasmic transport, bone remodeling, intracellular transport, lung alveolus development,rhythmic process, response to steroid hormone stimulus, embryonic organ morphogenesis, gut development,embryonic organ development, embryonic morphogenesis, reproductive process in a multicellular organism, embryonic cranial skeleton morphogenesis, embryonic neurocranium morphogenesis, embryonic skeletal system morphogenesis,skeletal system morphogenesis, embryonic skeletal system development, gland development, tissue remodeling, inner ear development, regulation of protein secretion, positive regulation of protein secretion, regulation of secretion,positive regulation of secretion, positive regulation of transport, regulation of DNA metabolic process, negative regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of developmental process, positive regulation of cellular component organization, nuclear transport, nuclear import,negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of protein transport, regulation of protein transport, positive regulation of multicellular organismal process, positive regulation of protein metabolic process,regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of cell division, regulation of transferase activity, positive regulation of transferase activity, regulation of filopodium assembly, positive regulation of filopodium assembly, detection of stimulus, positive regulation of cell division, palate development, regulation of cell development, regulation of cellular localization, bone development, bone morphogenesis, cranial suture morphogenesis, frontal suture morphogenesis, regulation of SMAD protein nuclear translocation, positive regulation of SMAD protein nuclear translocation, regulation of pathway-restricted SMAD protein phosphorylation, regulation of cell projection assembly, respiratory system development, negative regulation of cell death, regulation of biomineral formation, positive regulation of biomineral formation, regulation of establishment of protein localization, response to oxygen levels, detection of hypoxia, cellular macromolecule localization,
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