功能： regulation of DNA recombination, protein import into nucleus, translocation, cell cycle checkpoint, cell morphogenesis,cell morphogenesis involved in differentiation, skeletal system development, ossification, regulation of action potential,regulation of cell growth, response to hypoxia, morphogenesis of a branching structure, myeloid dendritic cell activation, cell activation, leukocyte homeostasis, regulation of cytokine production, positive regulation of cytokine production, epithelial to mesenchymal transition, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, healing during inflammatory response, connective tissue replacement during inflammatory response, lymphocyte homeostasis,myeloid leukocyte activation, tolerance induction, tolerance induction to self antigen, immune system development,leukocyte differentiation, myeloid leukocyte differentiation, regulation of immunoglobulin production, negative regulation of immune system process, positive regulation of immune system process, regulation of leukocyte activation, negative regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, regulation of B cell mediated immunity, regulation of adaptive immune response, regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, regulation of immunoglobulin mediated immune response, purine nucleotide metabolic process, purine nucleotide biosynthetic process, regulation of DNA replication, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly,protein amino acid phosphorylation, protein targeting, protein import into nucleus, protein export from nucleus, ATP biosynthetic process, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, intracellular protein transport, nucleocytoplasmic transport,induction of apoptosis, cell motion, defense response, inflammatory response, immune response, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, regulation of exit from mitosis, negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, SMAD protein complex assembly, SMAD protein nuclear translocation, ensheathment of neurons, gamete generation, regulation of mitotic cell cycle, negative regulation of neuroblast proliferation, sensory organ development,salivary gland development, salivary gland morphogenesis, endoderm development, female pregnancy, aging,response to nutrient, protein localization, negative regulation of DNA replication, cell death, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, germ cell migration, regulation of cell size, axon ensheathment, macromolecule catabolic process, nucleoside triphosphate metabolic process, nucleoside triphosphate biosynthetic process, purine nucleoside triphosphate metabolic process, purine nucleoside triphosphate biosynthetic process, purine ribonucleotide metabolic process, purine ribonucleotide biosynthetic process, nucleotide biosynthetic process, ribonucleoside triphosphate metabolic process, ribonucleoside triphosphate biosynthetic process, purine ribonucleoside triphosphate metabolic process, purine ribonucleoside triphosphate biosynthetic process,ribonucleotide metabolic process, ribonucleotide biosynthetic process, response to radiation, response to wounding,response to fungus, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus,response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, defense response, incompatible interaction, defense response to fungus, incompatible interaction, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of signal transduction, response to extracellular stimulus, response to organic substance, regulation of calcium ion transport into cytosol, negative regulation of calcium ion transport into cytosol, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, negative regulation of phosphorus metabolic process, regulation of cell cycle process, regulation of endothelial cell migration,positive regulation of endothelial cell migration, negative regulation of endothelial cell migration, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of gene expression, negative regulation of gene expression, positive regulation of cell communication, regulation of collagen metabolic process, positive regulation of collagen metabolic process,regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition, positive regulation of cell development, negative regulation of cell development, positive regulation of protein kinase cascade,foam cell differentiation, regulation of fibroblast migration, positive regulation of fibroblast migration, regulation of cell morphogenesis involved in differentiation, positive regulation of cell morphogenesis involved in differentiation,regulation of peptidyl-threonine phosphorylation, positive regulation of peptidyl-threonine phosphorylation, positive regulation of pathway-restricted SMAD protein phosphorylation, regulation of cell death, positive regulation of cell death, regulation of metal ion transport, induction of programmed cell death, mesenchymal cell development,response to organic cyclic substance, protein transport, viral reproduction, cell growth, regulation of striated muscle tissue development, death, phosphorylation, cell migration, negative regulation of transcription, regulation of transforming growth factor beta receptor signaling pathway, protein import, virus-host interaction, evasion of host defenses by virus, regulation of lipid metabolic process, regulation of phosphate metabolic process, transmission of nerve impulse, regulation of action potential in neuron, cellular homeostasis, sexual reproduction, cell cycle process,regulation of cell-cell adhesion, negative regulation of cell-cell adhesion, viral reproductive process, regulation of cell morphogenesis, gland morphogenesis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis,hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, regulation of endocytosis, regulation of cell adhesion, T cell differentiation, regulation of ossification, negative regulation of ossification, negative regulation of cell growth, regulation of cell migration, positive regulation of cell migration, negative regulation of cell migration,regulation of bone mineralization, positive regulation of bone mineralization, mammary gland development,regeneration, organ regeneration, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of protein modification process, negative regulation of protein modification process,positive regulation of protein modification process, positive regulation of exit from mitosis, G1/S transition checkpoint,response to nutrient levels, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process,positive regulation of cellular protein metabolic process, response to estradiol stimulus, regulation of intracellular transport, positive regulation of intracellular transport, multicellular organism reproduction, regulation of cellular component size, response to progesterone stimulus, regulation of interleukin-17 production, positive regulation of interleukin-17 production, receptor catabolic process, regulation of homeostatic process, negative regulation of homeostatic process, regulation of protein localization, mononuclear cell proliferation, regulation of mononuclear cell proliferation, negative regulation of mononuclear cell proliferation, regulation of collagen biosynthetic process, positive regulation of collagen biosynthetic process, cellular component morphogenesis, regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-serine phosphorylation, regulation of intracellular protein transport,regulation of protein import into nucleus, translocation, positive regulation of protein import into nucleus, translocation, response to vitamin, response to vitamin D, protein localization in organelle, positive regulation of kinase activity, response to lipid, response to monosaccharide stimulus, cell junction organization, nucleobase, nucleoside and nucleotide biosynthetic process, response to fluid shear stress, protein localization in nucleus, cellular protein localization, response to laminar fluid shear stress, cellular macromolecular complex subunit organization,cellular macromolecular complex assembly, nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process,exocrine system development, regulation of dephosphorylation, regulation of protein amino acid dephosphorylation,positive regulation of dephosphorylation, positive regulation of protein amino acid dephosphorylation, growth,regulation of growth, regulation of locomotion, negative regulation of locomotion, positive regulation of locomotion,wound healing, T cell activation, regulation of cell proliferation, regulation of T cell proliferation, negative regulation of T cell proliferation, regulation of protein import into nucleus, regulation of phosphorylation, negative regulation of phosphorylation, positive regulation of phosphorylation, regulation of membrane potential, odontogenesis, response to drug, myelination, homeostatic process, regulation of apoptosis, myeloid dendritic cell differentiation, T cell homeostasis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, receptor metabolic process, regulation of ion transport,negative regulation of ion transport, positive regulation of DNA binding, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of blood vessel endothelial cell migration, positive regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell migration, regulation of kinase activity, regulation of lipid kinase activity, regulation of phosphoinositide 3-kinase activity, positive regulation of phosphoinositide 3-kinase activity, ear development, cellular protein complex assembly, response to estrogen stimulus, ossification involved in bone remodeling, macromolecular complex subunit organization, positive regulation of molecular function, regulation of multicellular organismal metabolic process, positive regulation of multicellular organismal metabolic process, nitrogen compound biosynthetic process, avoidance of host defenses, evasion or tolerance of host defenses, regulatory T cell differentiation, innate immune response, establishment of protein localization, regulation of isotype switching, cell-cell junction organization, leukocyte activation, regulation of transcription, negative regulation of cell differentiation, positive regulation of cell differentiation, positive regulation of ossification, negative regulation of cell cycle, negative regulation of cell size, negative regulation of endocytosis,positive regulation of isotype switching, positive regulation of lipid metabolic process, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of DNA recombination, negative regulation of growth, negative regulation of mitotic cell cycle, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of phosphate metabolic process,positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, ATP metabolic process, lymphocyte activation, regulation of nucleocytoplasmic transport, bone remodeling, intracellular transport, regulation of isotype switching to IgA isotypes,positive regulation of isotype switching to IgA isotypes, positive regulation of behavior, hemopoietic or lymphoid organ development, lymph node development, response to steroid hormone stimulus, gut development, positive regulation of response to stimulus, negative regulation of response to stimulus, reproductive process in a multicellular organism,reproductive cellular process, regulation of muscle development, skeletal system morphogenesis, gland development,mesenchymal cell differentiation, tissue remodeling, inner ear development, cell motility, homeostasis of number of cells, chemical homeostasis, regulation of lymphocyte proliferation, negative regulation of lymphocyte proliferation,regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation, regulation of protein secretion, positive regulation of protein secretion, regulation of phagocytosis, negative regulation of phagocytosis, regulation of neurogenesis, negative regulation of neurogenesis,negative regulation of immune response, regulation of behavior, ion homeostasis, defense response to fungus,regulation of T cell activation, regulation of B cell activation, regulation of cell activation, negative regulation of cell activation, positive regulation of cell activation, negative regulation of T cell activation, positive regulation of B cell activation, neurological system process, regulation of chemotaxis, positive regulation of chemotaxis, regulation of secretion, positive regulation of secretion, positive regulation of transport, negative regulation of transport, regulation of DNA metabolic process, negative regulation of DNA metabolic process, positive regulation of DNA metabolic process,regulation of transcription factor activity, positive regulation of transcription factor activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of developmental process, regulation of binding, positive regulation of binding, regulation of DNA binding, negative regulation of cellular component organization, positive regulation of cellular component organization, nuclear export, nuclear transport, nuclear import, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of protein transport, regulation of protein transport, positive regulation of multicellular organismal process, positive regulation of protein metabolic process, negative regulation of protein metabolic process, regulation of lymphocyte activation, negative regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of RNA metabolic process, positive regulation of RNA metabolic process,regulation of cell motion, negative regulation of cell motion, positive regulation of cell motion, regulation of release of sequestered calcium ion into cytosol, negative regulation of release of sequestered calcium ion into cytosol, regulation of cell division, regulation of transferase activity, positive regulation of transferase activity, localization of cell,regulation of cell cycle, positive regulation of cell division, response to protein stimulus, avoidance of defenses of other organism during symbiotic interaction, evasion or tolerance of defenses of other organism during symbiotic interaction,regulation of protein kinase B signaling cascade, positive regulation of protein kinase B signaling cascade, regulation of calcium ion transport, negative regulation of calcium ion transport, regulation of nervous system development,response to defenses of other organism during symbiotic interaction, response to host defenses, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, regulation of cell development, regulation of cellular localization, bone development, bone morphogenesis, cranial suture morphogenesis, frontal suture morphogenesis, pathway-restricted SMAD protein phosphorylation, regulation of SMAD protein nuclear translocation, positive regulation of SMAD protein nuclear translocation, regulation of pathway-restricted SMAD protein phosphorylation, mesenchyme development, regulation of vesicle-mediated transport, macromolecular complex assembly, regulation of biomineral formation, positive regulation of biomineral formation, regulation of establishment of protein localization, protein complex biogenesis,response to oxygen levels, leukocyte proliferation, regulation of leukocyte proliferation, negative regulation of leukocyte proliferation, response to cholesterol, cellular macromolecule localization, response to host,
组织表达： Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
科研货号： PLA001185
Total TGFβ1 Cell-Based Colorimetric ELISA Kit
Catalog NoPLA001185
Product information
发货日期： 14
基因名称： TGFB1 TGFB
蛋白名称： Transforming growth factor beta-1, TGF-β1, TGF b
功能： regulation of DNA recombination, protein import into nucleus, translocation, cell cycle checkpoint, cell morphogenesis,cell morphogenesis involved in differentiation, skeletal system development, ossification, regulation of action potential,regulation of cell growth, response to hypoxia, morphogenesis of a branching structure, myeloid dendritic cell activation, cell activation, leukocyte homeostasis, regulation of cytokine production, positive regulation of cytokine production, epithelial to mesenchymal transition, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, healing during inflammatory response, connective tissue replacement during inflammatory response, lymphocyte homeostasis,myeloid leukocyte activation, tolerance induction, tolerance induction to self antigen, immune system development,leukocyte differentiation, myeloid leukocyte differentiation, regulation of immunoglobulin production, negative regulation of immune system process, positive regulation of immune system process, regulation of leukocyte activation, negative regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, regulation of B cell mediated immunity, regulation of adaptive immune response, regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, regulation of immunoglobulin mediated immune response, purine nucleotide metabolic process, purine nucleotide biosynthetic process, regulation of DNA replication, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly,protein amino acid phosphorylation, protein targeting, protein import into nucleus, protein export from nucleus, ATP biosynthetic process, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, intracellular protein transport, nucleocytoplasmic transport,induction of apoptosis, cell motion, defense response, inflammatory response, immune response, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, regulation of exit from mitosis, negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, epidermal growth factor receptor signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, SMAD protein complex assembly, SMAD protein nuclear translocation, ensheathment of neurons, gamete generation, regulation of mitotic cell cycle, negative regulation of neuroblast proliferation, sensory organ development,salivary gland development, salivary gland morphogenesis, endoderm development, female pregnancy, aging,response to nutrient, protein localization, negative regulation of DNA replication, cell death, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, germ cell migration, regulation of cell size, axon ensheathment, macromolecule catabolic process, nucleoside triphosphate metabolic process, nucleoside triphosphate biosynthetic process, purine nucleoside triphosphate metabolic process, purine nucleoside triphosphate biosynthetic process, purine ribonucleotide metabolic process, purine ribonucleotide biosynthetic process, nucleotide biosynthetic process, ribonucleoside triphosphate metabolic process, ribonucleoside triphosphate biosynthetic process, purine ribonucleoside triphosphate metabolic process, purine ribonucleoside triphosphate biosynthetic process,ribonucleotide metabolic process, ribonucleotide biosynthetic process, response to radiation, response to wounding,response to fungus, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus,response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, defense response, incompatible interaction, defense response to fungus, incompatible interaction, negative regulation of biosynthetic process, positive regulation of biosynthetic process, positive regulation of signal transduction, response to extracellular stimulus, response to organic substance, regulation of calcium ion transport into cytosol, negative regulation of calcium ion transport into cytosol, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, negative regulation of phosphorus metabolic process, regulation of cell cycle process, regulation of endothelial cell migration,positive regulation of endothelial cell migration, negative regulation of endothelial cell migration, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of gene expression, negative regulation of gene expression, positive regulation of cell communication, regulation of collagen metabolic process, positive regulation of collagen metabolic process,regulation of epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition, positive regulation of cell development, negative regulation of cell development, positive regulation of protein kinase cascade,foam cell differentiation, regulation of fibroblast migration, positive regulation of fibroblast migration, regulation of cell morphogenesis involved in differentiation, positive regulation of cell morphogenesis involved in differentiation,regulation of peptidyl-threonine phosphorylation, positive regulation of peptidyl-threonine phosphorylation, positive regulation of pathway-restricted SMAD protein phosphorylation, regulation of cell death, positive regulation of cell death, regulation of metal ion transport, induction of programmed cell death, mesenchymal cell development,response to organic cyclic substance, protein transport, viral reproduction, cell growth, regulation of striated muscle tissue development, death, phosphorylation, cell migration, negative regulation of transcription, regulation of transforming growth factor beta receptor signaling pathway, protein import, virus-host interaction, evasion of host defenses by virus, regulation of lipid metabolic process, regulation of phosphate metabolic process, transmission of nerve impulse, regulation of action potential in neuron, cellular homeostasis, sexual reproduction, cell cycle process,regulation of cell-cell adhesion, negative regulation of cell-cell adhesion, viral reproductive process, regulation of cell morphogenesis, gland morphogenesis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis,hemopoiesis, lymphocyte differentiation, myeloid cell differentiation, regulation of endocytosis, regulation of cell adhesion, T cell differentiation, regulation of ossification, negative regulation of ossification, negative regulation of cell growth, regulation of cell migration, positive regulation of cell migration, negative regulation of cell migration,regulation of bone mineralization, positive regulation of bone mineralization, mammary gland development,regeneration, organ regeneration, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of protein modification process, negative regulation of protein modification process,positive regulation of protein modification process, positive regulation of exit from mitosis, G1/S transition checkpoint,response to nutrient levels, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process,positive regulation of cellular protein metabolic process, response to estradiol stimulus, regulation of intracellular transport, positive regulation of intracellular transport, multicellular organism reproduction, regulation of cellular component size, response to progesterone stimulus, regulation of interleukin-17 production, positive regulation of interleukin-17 production, receptor catabolic process, regulation of homeostatic process, negative regulation of homeostatic process, regulation of protein localization, mononuclear cell proliferation, regulation of mononuclear cell proliferation, negative regulation of mononuclear cell proliferation, regulation of collagen biosynthetic process, positive regulation of collagen biosynthetic process, cellular component morphogenesis, regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-serine phosphorylation, regulation of intracellular protein transport,regulation of protein import into nucleus, translocation, positive regulation of protein import into nucleus, translocation, response to vitamin, response to vitamin D, protein localization in organelle, positive regulation of kinase activity, response to lipid, response to monosaccharide stimulus, cell junction organization, nucleobase, nucleoside and nucleotide biosynthetic process, response to fluid shear stress, protein localization in nucleus, cellular protein localization, response to laminar fluid shear stress, cellular macromolecular complex subunit organization,cellular macromolecular complex assembly, nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process,exocrine system development, regulation of dephosphorylation, regulation of protein amino acid dephosphorylation,positive regulation of dephosphorylation, positive regulation of protein amino acid dephosphorylation, growth,regulation of growth, regulation of locomotion, negative regulation of locomotion, positive regulation of locomotion,wound healing, T cell activation, regulation of cell proliferation, regulation of T cell proliferation, negative regulation of T cell proliferation, regulation of protein import into nucleus, regulation of phosphorylation, negative regulation of phosphorylation, positive regulation of phosphorylation, regulation of membrane potential, odontogenesis, response to drug, myelination, homeostatic process, regulation of apoptosis, myeloid dendritic cell differentiation, T cell homeostasis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, receptor metabolic process, regulation of ion transport,negative regulation of ion transport, positive regulation of DNA binding, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of blood vessel endothelial cell migration, positive regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell migration, regulation of kinase activity, regulation of lipid kinase activity, regulation of phosphoinositide 3-kinase activity, positive regulation of phosphoinositide 3-kinase activity, ear development, cellular protein complex assembly, response to estrogen stimulus, ossification involved in bone remodeling, macromolecular complex subunit organization, positive regulation of molecular function, regulation of multicellular organismal metabolic process, positive regulation of multicellular organismal metabolic process, nitrogen compound biosynthetic process, avoidance of host defenses, evasion or tolerance of host defenses, regulatory T cell differentiation, innate immune response, establishment of protein localization, regulation of isotype switching, cell-cell junction organization, leukocyte activation, regulation of transcription, negative regulation of cell differentiation, positive regulation of cell differentiation, positive regulation of ossification, negative regulation of cell cycle, negative regulation of cell size, negative regulation of endocytosis,positive regulation of isotype switching, positive regulation of lipid metabolic process, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of DNA recombination, negative regulation of growth, negative regulation of mitotic cell cycle, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of phosphate metabolic process,positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, ATP metabolic process, lymphocyte activation, regulation of nucleocytoplasmic transport, bone remodeling, intracellular transport, regulation of isotype switching to IgA isotypes,positive regulation of isotype switching to IgA isotypes, positive regulation of behavior, hemopoietic or lymphoid organ development, lymph node development, response to steroid hormone stimulus, gut development, positive regulation of response to stimulus, negative regulation of response to stimulus, reproductive process in a multicellular organism,reproductive cellular process, regulation of muscle development, skeletal system morphogenesis, gland development,mesenchymal cell differentiation, tissue remodeling, inner ear development, cell motility, homeostasis of number of cells, chemical homeostasis, regulation of lymphocyte proliferation, negative regulation of lymphocyte proliferation,regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation, regulation of protein secretion, positive regulation of protein secretion, regulation of phagocytosis, negative regulation of phagocytosis, regulation of neurogenesis, negative regulation of neurogenesis,negative regulation of immune response, regulation of behavior, ion homeostasis, defense response to fungus,regulation of T cell activation, regulation of B cell activation, regulation of cell activation, negative regulation of cell activation, positive regulation of cell activation, negative regulation of T cell activation, positive regulation of B cell activation, neurological system process, regulation of chemotaxis, positive regulation of chemotaxis, regulation of secretion, positive regulation of secretion, positive regulation of transport, negative regulation of transport, regulation of DNA metabolic process, negative regulation of DNA metabolic process, positive regulation of DNA metabolic process,regulation of transcription factor activity, positive regulation of transcription factor activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of developmental process, regulation of binding, positive regulation of binding, regulation of DNA binding, negative regulation of cellular component organization, positive regulation of cellular component organization, nuclear export, nuclear transport, nuclear import, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of protein transport, regulation of protein transport, positive regulation of multicellular organismal process, positive regulation of protein metabolic process, negative regulation of protein metabolic process, regulation of lymphocyte activation, negative regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of RNA metabolic process, positive regulation of RNA metabolic process,regulation of cell motion, negative regulation of cell motion, positive regulation of cell motion, regulation of release of sequestered calcium ion into cytosol, negative regulation of release of sequestered calcium ion into cytosol, regulation of cell division, regulation of transferase activity, positive regulation of transferase activity, localization of cell,regulation of cell cycle, positive regulation of cell division, response to protein stimulus, avoidance of defenses of other organism during symbiotic interaction, evasion or tolerance of defenses of other organism during symbiotic interaction,regulation of protein kinase B signaling cascade, positive regulation of protein kinase B signaling cascade, regulation of calcium ion transport, negative regulation of calcium ion transport, regulation of nervous system development,response to defenses of other organism during symbiotic interaction, response to host defenses, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, regulation of cell development, regulation of cellular localization, bone development, bone morphogenesis, cranial suture morphogenesis, frontal suture morphogenesis, pathway-restricted SMAD protein phosphorylation, regulation of SMAD protein nuclear translocation, positive regulation of SMAD protein nuclear translocation, regulation of pathway-restricted SMAD protein phosphorylation, mesenchyme development, regulation of vesicle-mediated transport, macromolecular complex assembly, regulation of biomineral formation, positive regulation of biomineral formation, regulation of establishment of protein localization, protein complex biogenesis,response to oxygen levels, leukocyte proliferation, regulation of leukocyte proliferation, negative regulation of leukocyte proliferation, response to cholesterol, cellular macromolecule localization, response to host,
组织表达： Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
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