功能： DNA metabolic process, DNA replication, regulation of DNA replication, DNA repair, base-excision repair, base-excision repair, gap-filling, nucleotide-excision repair, nucleotide-excision repair, DNA gap filling, mismatch repair, intracellular protein transport, response to DNA damage stimulus, intracellular signaling cascade, protein localization, cell proliferation, protein transport, second-messenger-mediated signaling, cellular response to stress, cellular protein localization, establishment of protein localization, intracellular transport, phosphoinositide-mediated signaling,regulation of DNA metabolic process, cellular macromolecule localization,
细胞定位： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
功能： DNA metabolic process, DNA replication, regulation of DNA replication, DNA repair, base-excision repair, base-excision repair, gap-filling, nucleotide-excision repair, nucleotide-excision repair, DNA gap filling, mismatch repair, intracellular protein transport, response to DNA damage stimulus, intracellular signaling cascade, protein localization, cell proliferation, protein transport, second-messenger-mediated signaling, cellular response to stress, cellular protein localization, establishment of protein localization, intracellular transport, phosphoinositide-mediated signaling,regulation of DNA metabolic process, cellular macromolecule localization,
细胞定位： Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
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