其他名称： E3 ubiquitin-protein ligase parkin (EC 6.3.2.-) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
功能： neurotransmitter uptake, regulation of neurotransmitter levels, synaptic transmission, dopaminergic, startle response,proteolysis, ubiquitin-dependent protein catabolic process, ubiquitin cycle, cellular amino acid derivative metabolic process, biogenic amine metabolic process, catecholamine metabolic process, neurotransmitter transport, cell-cell signaling, synaptic transmission, nerve-nerve synaptic transmission, behavior, learning or memory, learning,locomotory behavior, adult locomotory behavior, macromolecule catabolic process, catechol metabolic process, amine transport, monoamine transport, organic alcohol transport, dopamine transport, protein ubiquitination, phenol metabolic process, transmission of nerve impulse, modification-dependent protein catabolic process, protein catabolic process, adult behavior, regulation of neurological system process, protein modification by small protein conjugation,diol metabolic process, synaptic transmission, glutamatergic, norepinephrine metabolic process, dopamine metabolic process, protein ubiquitination during ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, regulation of system process, cellular protein catabolic process, cellular macromolecule catabolic process, regulation of neurotransmitter secretion, regulation of synaptic transmission,neurological system process, cognition, neuromuscular process, regulation of secretion, dopamine uptake, regulation of neurotransmitter transport, proteolysis involved in cellular protein catabolic process, catecholamine uptake during transmission of nerve impulse, catecholamine transport, regulation of transmission of nerve impulse, regulation of cellular localization, protein modification by small protein conjugation or removal,
相关产品： YT3593,YT3591,YP0962,KA4220C,KA3353C
细胞定位： Cytoplasm, cytosol . Nucleus . Endoplasmic reticulum . Mitochondrion . Mitochondrion outer membrane . Cell projection, neuron projection . Cell junction, synapse, postsynaptic density . Cell junction, synapse, presynapse . Mainly localizes in the cytosol (PubMed:19029340, PubMed:19229105). Co-localizes with SYT11 in neutrites (PubMed:12925569). Co-localizes with SNCAIP in brainstem Lewy bodies (PubMed:10319893, PubMed:11431533). Translocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051). Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830). .
组织表达： Highly expressed in the brain including the substantia nigra (PubMed:9560156, PubMed:19501131). Expressed in heart, testis and skeletal muscle (PubMed:9560156). Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients (PubMed:14614460, PubMed:12719539). Overexpression protects dopamine neurons from kainate-mediated apoptosis (PubMed:12628165). Found in serum (at protein level) (PubMed:19501131).
其他名称： E3 ubiquitin-protein ligase parkin (EC 6.3.2.-) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
功能： neurotransmitter uptake, regulation of neurotransmitter levels, synaptic transmission, dopaminergic, startle response,proteolysis, ubiquitin-dependent protein catabolic process, ubiquitin cycle, cellular amino acid derivative metabolic process, biogenic amine metabolic process, catecholamine metabolic process, neurotransmitter transport, cell-cell signaling, synaptic transmission, nerve-nerve synaptic transmission, behavior, learning or memory, learning,locomotory behavior, adult locomotory behavior, macromolecule catabolic process, catechol metabolic process, amine transport, monoamine transport, organic alcohol transport, dopamine transport, protein ubiquitination, phenol metabolic process, transmission of nerve impulse, modification-dependent protein catabolic process, protein catabolic process, adult behavior, regulation of neurological system process, protein modification by small protein conjugation,diol metabolic process, synaptic transmission, glutamatergic, norepinephrine metabolic process, dopamine metabolic process, protein ubiquitination during ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, regulation of system process, cellular protein catabolic process, cellular macromolecule catabolic process, regulation of neurotransmitter secretion, regulation of synaptic transmission,neurological system process, cognition, neuromuscular process, regulation of secretion, dopamine uptake, regulation of neurotransmitter transport, proteolysis involved in cellular protein catabolic process, catecholamine uptake during transmission of nerve impulse, catecholamine transport, regulation of transmission of nerve impulse, regulation of cellular localization, protein modification by small protein conjugation or removal,
相关产品： YT3593,YT3591,YP0962,KA4220C,KA3353C
细胞定位： Cytoplasm, cytosol . Nucleus . Endoplasmic reticulum . Mitochondrion . Mitochondrion outer membrane . Cell projection, neuron projection . Cell junction, synapse, postsynaptic density . Cell junction, synapse, presynapse . Mainly localizes in the cytosol (PubMed:19029340, PubMed:19229105). Co-localizes with SYT11 in neutrites (PubMed:12925569). Co-localizes with SNCAIP in brainstem Lewy bodies (PubMed:10319893, PubMed:11431533). Translocates to dysfunctional mitochondria that have lost the mitochondrial membrane potential; recruitment to mitochondria is PINK1-dependent (PubMed:24898855, PubMed:18957282, PubMed:19966284, PubMed:23620051). Mitochondrial localization also gradually increases with cellular growth (PubMed:22082830). .
组织表达： Highly expressed in the brain including the substantia nigra (PubMed:9560156, PubMed:19501131). Expressed in heart, testis and skeletal muscle (PubMed:9560156). Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients (PubMed:14614460, PubMed:12719539). Overexpression protects dopamine neurons from kainate-mediated apoptosis (PubMed:12628165). Found in serum (at protein level) (PubMed:19501131).
在线咨询
湘公网安备