其他名称： Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
功能： microtubule cytoskeleton organization, regulation of cell growth, cytoskeleton organization, microtubule-based process, negative regulation of microtubule depolymerization, regulation of cell size, positive regulation of organelle organization, negative regulation of organelle organization, positive regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of neuron projection development, regulation of cell morphogenesis, positive regulation of cell growth, regulation of axon extension, regulation of microtubule polymerization or depolymerization, negative regulation of microtubule polymerization or depolymerization, positive regulation of microtubule polymerization or depolymerization, regulation of microtubule polymerization, regulation of microtubule depolymerization, positive regulation of microtubule polymerization, positive regulation of protein complex assembly, regulation of cell projection organization, positive regulation of cell projection organization, regulation of protein polymerization, positive regulation of protein polymerization, regulation of cellular component size, regulation of microtubule-based process, regulation of organelle organization, regulation of growth, negative regulation of protein complex disassembly, regulation of protein complex disassembly, regulation of protein complex assembly,regulation of cellular component biogenesis, positive regulation of cell differentiation, regulation of neuron differentiation, positive regulation of axon extension, positive regulation of cell size, positive regulation of growth,regulation of developmental growth, positive regulation of developmental growth, regulation of neurogenesis, positive regulation of neurogenesis, regulation of axonogenesis, positive regulation of axonogenesis, positive regulation of developmental process, negative regulation of cellular component organization, positive regulation of cellular component organization, regulation of cytoskeleton organization, negative regulation of cytoskeleton organization,positive regulation of cytoskeleton organization, regulation of nervous system development, regulation of cell development, regulation of microtubule cytoskeleton organization,
细胞定位： Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
组织表达： Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
其他名称： Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
功能： microtubule cytoskeleton organization, regulation of cell growth, cytoskeleton organization, microtubule-based process, negative regulation of microtubule depolymerization, regulation of cell size, positive regulation of organelle organization, negative regulation of organelle organization, positive regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of neuron projection development, regulation of cell morphogenesis, positive regulation of cell growth, regulation of axon extension, regulation of microtubule polymerization or depolymerization, negative regulation of microtubule polymerization or depolymerization, positive regulation of microtubule polymerization or depolymerization, regulation of microtubule polymerization, regulation of microtubule depolymerization, positive regulation of microtubule polymerization, positive regulation of protein complex assembly, regulation of cell projection organization, positive regulation of cell projection organization, regulation of protein polymerization, positive regulation of protein polymerization, regulation of cellular component size, regulation of microtubule-based process, regulation of organelle organization, regulation of growth, negative regulation of protein complex disassembly, regulation of protein complex disassembly, regulation of protein complex assembly,regulation of cellular component biogenesis, positive regulation of cell differentiation, regulation of neuron differentiation, positive regulation of axon extension, positive regulation of cell size, positive regulation of growth,regulation of developmental growth, positive regulation of developmental growth, regulation of neurogenesis, positive regulation of neurogenesis, regulation of axonogenesis, positive regulation of axonogenesis, positive regulation of developmental process, negative regulation of cellular component organization, positive regulation of cellular component organization, regulation of cytoskeleton organization, negative regulation of cytoskeleton organization,positive regulation of cytoskeleton organization, regulation of nervous system development, regulation of cell development, regulation of microtubule cytoskeleton organization,
细胞定位： Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
组织表达： Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
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