功能： G1 phase of mitotic cell cycle, negative regulation of transcription from RNA polymerase II promoter, mitotic cell cycle,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly, proteolysis, ubiquitin-dependent protein catabolic process, cell cycle, traversing start control point of mitotic cell cycle, regulation of mitotic cell cycle, positive regulation of cell proliferation, macromolecule catabolic process, negative regulation of biosynthetic process, regulation of catabolic process, positive regulation of catabolic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription, protein ubiquitination, modification-dependent protein catabolic process, cell cycle process,cell cycle phase, regulation of proteolysis, protein catabolic process, negative regulation of cellular biosynthetic process, regulation of cellular catabolic process, positive regulation of cellular catabolic process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein modification by small protein conjugation, regulation of cell proliferation, regulation of protein catabolic process, protein ubiquitination during ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, macromolecular complex subunit organization, cellular protein catabolic process, cellular macromolecule catabolic process, regulation of transcription, positive regulation of protein catabolic process, positive regulation of cell cycle, positive regulation of proteolysis, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of nitrogen compound metabolic process, positive regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, G1 phase, interphase, interphase of mitotic cell cycle, proteolysis involved in cellular protein catabolic process, regulation of cell cycle, macromolecular complex assembly, protein complex biogenesis, protein modification by small protein conjugation or removal,
细胞定位： Nucleus, nucleoplasm. Cytoplasm . Nucleus, nucleolus. Nucleus . Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
组织表达： Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
功能： G1 phase of mitotic cell cycle, negative regulation of transcription from RNA polymerase II promoter, mitotic cell cycle,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly, proteolysis, ubiquitin-dependent protein catabolic process, cell cycle, traversing start control point of mitotic cell cycle, regulation of mitotic cell cycle, positive regulation of cell proliferation, macromolecule catabolic process, negative regulation of biosynthetic process, regulation of catabolic process, positive regulation of catabolic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription, protein ubiquitination, modification-dependent protein catabolic process, cell cycle process,cell cycle phase, regulation of proteolysis, protein catabolic process, negative regulation of cellular biosynthetic process, regulation of cellular catabolic process, positive regulation of cellular catabolic process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein modification by small protein conjugation, regulation of cell proliferation, regulation of protein catabolic process, protein ubiquitination during ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, macromolecular complex subunit organization, cellular protein catabolic process, cellular macromolecule catabolic process, regulation of transcription, positive regulation of protein catabolic process, positive regulation of cell cycle, positive regulation of proteolysis, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of nitrogen compound metabolic process, positive regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, G1 phase, interphase, interphase of mitotic cell cycle, proteolysis involved in cellular protein catabolic process, regulation of cell cycle, macromolecular complex assembly, protein complex biogenesis, protein modification by small protein conjugation or removal,
细胞定位： Nucleus, nucleoplasm. Cytoplasm . Nucleus, nucleolus. Nucleus . Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
组织表达： Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
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