功能： protein import into nucleus, translocation, regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, polysaccharide biosynthetic process, mitotic cell cycle, regulation of cell growth, blood vessel development, leukocyte homeostasis, placenta development, hair follicle development, vasculature development,regulation of sodium ion transport, lymphocyte homeostasis, reproductive developmental process, polysaccharide metabolic process, glycogen metabolic process, glycogen biosynthetic process, regulation of glycogen biosynthetic process, monosaccharide metabolic process, glucose metabolic process, cellular glucan metabolic process, generation of precursor metabolites and energy, regulation of carbohydrate metabolic process, energy reserve metabolic process,regulation of translation, protein amino acid phosphorylation, negative regulation of protein kinase activity, protein targeting, protein import into nucleus, phosphorus metabolic process, phosphate metabolic process, nitric oxide biosynthetic process, intracellular protein transport, nucleocytoplasmic transport, apoptosis, anti-apoptosis,activation-induced cell death of T cells, defense response, inflammatory response, mitochondrion organization, cell cycle, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, G-protein coupled receptor protein signaling pathway, intracellular signaling cascade, protein kinase cascade, gamete generation, germ cell development,ectoderm development, protein localization, cell death, insulin receptor signaling pathway, regulation of cell size,epidermis development, activation of pro-apoptotic gene products, apoptotic mitochondrial changes, carbohydrate transport, hexose transport, macromolecule catabolic process, glucan biosynthetic process, response to temperature stimulus, response to radiation, response to heat, response to UV, response to light stimulus, response to wounding,response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, positive regulation of catabolic process, negative regulation of signal transduction, response to extracellular stimulus, response to organic substance, positive regulation of macromolecule biosynthetic process, regulation of cellular ketone metabolic process,positive regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, regulation of protein kinase cascade, negative regulation of cell communication, regulation of cellular carbohydrate metabolic process, positive regulation of cellular carbohydrate metabolic process, negative regulation of protein kinase cascade,regulation of plasma membrane long-chain fatty acid transport, negative regulation of plasma membrane long-chain fatty acid transport, positive regulation of sodium ion transport, regulation of glucose transport, positive regulation of glucose transport, regulation of glucose metabolic process, positive regulation of glucose metabolic process,regulation of cell death, positive regulation of cell death, regulation of metal ion transport, regulation of glucan biosynthetic process, programmed cell death, protein transport, monosaccharide transport, glucose transport, energy derivation by oxidation of organic compounds, carbohydrate biosynthetic process, death, phosphorylation, protein ubiquitination, protein import, peptidyl-serine phosphorylation, peptidyl-serine modification, regulation of lipid metabolic process, regulation of fatty acid metabolic process, regulation of phosphate metabolic process, hexose metabolic process, sexual reproduction, developmental maturation, cell cycle process, cell cycle phase, molting cycle process, hair cycle process, cell projection organization, regulation of proteolysis, protein catabolic process, positive regulation of cell growth, regulation of cell migration, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, negative regulation of cellular catabolic process, positive regulation of cellular catabolic process, regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of cyclin-dependent protein kinase activity during G1/S, response to nutrient levels, regulation of fatty acid beta-oxidation, negative regulation of fatty acid beta-oxidation, response to food, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of lipid transport, negative regulation of lipid transport,regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein modification by small protein conjugation, multicellular organism reproduction, regulation of cellular component size, regulation of monooxygenase activity, positive regulation of monooxygenase activity, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, regulation of protein localization, regulation of polysaccharide metabolic process, regulation of polysaccharide biosynthetic process, regulation of organic acid transport, negative regulation of organic acid transport, protein localization in organelle, negative regulation of kinase activity, positive regulation of kinase activity,cellular polysaccharide biosynthetic process, response to fluid shear stress, protein localization in nucleus, cellular protein localization, cellular carbohydrate biosynthetic process, growth, regulation of growth, regulation of locomotion,regulation of multicellular organism growth, positive regulation of multicellular organism growth, regulation of protein catabolic process, molting cycle, regulation of phosphorylation, homeostatic process, hair cycle, anagen, regulation of apoptosis, T cell homeostasis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,positive regulation of catalytic activity, negative regulation of catalytic activity, regulation of carbohydrate biosynthetic process, regulation of ion transport, positive regulation of ion transport, regulation of MAPKKK cascade, negative regulation of MAPKKK cascade, response to peptide hormone stimulus, regulation of generation of precursor metabolites and energy, protein kinase B signaling cascade, regulation of kinase activity, glucan metabolic process,negative regulation of molecular function, positive regulation of molecular function, cellular polysaccharide metabolic process, nitrogen compound biosynthetic process, establishment of protein localization, regulation of nitric oxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of cell differentiation,regulation of fat cell differentiation, positive regulation of fat cell differentiation, positive regulation of glycogen biosynthetic process, positive regulation of protein catabolic process, positive regulation of cyclin-dependent protein kinase activity, positive regulation of cell cycle, negative regulation of cell size, positive regulation of cell size, negative regulation of lipid metabolic process, positive regulation of lipid metabolic process, regulation of protein kinase activity,positive regulation of protein kinase activity, positive regulation of proteolysis, regulation of survival gene product expression, positive regulation of carbohydrate metabolic process, negative regulation of fatty acid metabolic process,positive regulation of growth, nitric oxide metabolic process, regulation of fatty acid oxidation, negative regulation of fatty acid oxidation, regulation of glucose import, positive regulation of glucose import, regulation of JNK cascade,negative regulation of JNK cascade, protein amino acid autophosphorylation, positive regulation of lipid biosynthetic process, regulation of lipid biosynthetic process, intracellular transport, insulin-like growth factor receptor signaling pathway, negative regulation of response to stimulus, developmental growth, reproductive process in a multicellular organism, reproductive cellular process, hair follicle maturation, homeostasis of number of cells, regulation of lipid catabolic process, negative regulation of lipid catabolic process, regulation of nitric-oxide synthase activity, positive regulation of nitric-oxide synthase activity, positive regulation of transport, negative regulation of transport, positive regulation of developmental process, positive regulation of cellular component organization, nuclear transport, nuclear import, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process,positive regulation of multicellular organismal process, positive regulation of protein metabolic process, regulation of cell motion, interphase, interphase of mitotic cell cycle, regulation of transferase activity, regulation of oxidoreductase activity, positive regulation of transferase activity, negative regulation of transferase activity, positive regulation of oxidoreductase activity, regulation of cell cycle, negative regulation of cell death, response to UV-A, regulation of establishment of protein localization, lymphocyte apoptosis, T cell apoptosis, regulation of stress-activated protein kinase signaling pathway, negative regulation of stress-activated protein kinase signaling pathway, protein modification by small protein conjugation or removal, cellular macromolecule localization, regulation of cellular response to stress, regulation of establishment of protein localization to plasma membrane, positive regulation of establishment of protein localization to plasma membrane,
细胞定位： Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
组织表达： Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
功能： protein import into nucleus, translocation, regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, polysaccharide biosynthetic process, mitotic cell cycle, regulation of cell growth, blood vessel development, leukocyte homeostasis, placenta development, hair follicle development, vasculature development,regulation of sodium ion transport, lymphocyte homeostasis, reproductive developmental process, polysaccharide metabolic process, glycogen metabolic process, glycogen biosynthetic process, regulation of glycogen biosynthetic process, monosaccharide metabolic process, glucose metabolic process, cellular glucan metabolic process, generation of precursor metabolites and energy, regulation of carbohydrate metabolic process, energy reserve metabolic process,regulation of translation, protein amino acid phosphorylation, negative regulation of protein kinase activity, protein targeting, protein import into nucleus, phosphorus metabolic process, phosphate metabolic process, nitric oxide biosynthetic process, intracellular protein transport, nucleocytoplasmic transport, apoptosis, anti-apoptosis,activation-induced cell death of T cells, defense response, inflammatory response, mitochondrion organization, cell cycle, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, G-protein coupled receptor protein signaling pathway, intracellular signaling cascade, protein kinase cascade, gamete generation, germ cell development,ectoderm development, protein localization, cell death, insulin receptor signaling pathway, regulation of cell size,epidermis development, activation of pro-apoptotic gene products, apoptotic mitochondrial changes, carbohydrate transport, hexose transport, macromolecule catabolic process, glucan biosynthetic process, response to temperature stimulus, response to radiation, response to heat, response to UV, response to light stimulus, response to wounding,response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, positive regulation of catabolic process, negative regulation of signal transduction, response to extracellular stimulus, response to organic substance, positive regulation of macromolecule biosynthetic process, regulation of cellular ketone metabolic process,positive regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, regulation of protein kinase cascade, negative regulation of cell communication, regulation of cellular carbohydrate metabolic process, positive regulation of cellular carbohydrate metabolic process, negative regulation of protein kinase cascade,regulation of plasma membrane long-chain fatty acid transport, negative regulation of plasma membrane long-chain fatty acid transport, positive regulation of sodium ion transport, regulation of glucose transport, positive regulation of glucose transport, regulation of glucose metabolic process, positive regulation of glucose metabolic process,regulation of cell death, positive regulation of cell death, regulation of metal ion transport, regulation of glucan biosynthetic process, programmed cell death, protein transport, monosaccharide transport, glucose transport, energy derivation by oxidation of organic compounds, carbohydrate biosynthetic process, death, phosphorylation, protein ubiquitination, protein import, peptidyl-serine phosphorylation, peptidyl-serine modification, regulation of lipid metabolic process, regulation of fatty acid metabolic process, regulation of phosphate metabolic process, hexose metabolic process, sexual reproduction, developmental maturation, cell cycle process, cell cycle phase, molting cycle process, hair cycle process, cell projection organization, regulation of proteolysis, protein catabolic process, positive regulation of cell growth, regulation of cell migration, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, negative regulation of cellular catabolic process, positive regulation of cellular catabolic process, regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of cyclin-dependent protein kinase activity during G1/S, response to nutrient levels, regulation of fatty acid beta-oxidation, negative regulation of fatty acid beta-oxidation, response to food, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of lipid transport, negative regulation of lipid transport,regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein modification by small protein conjugation, multicellular organism reproduction, regulation of cellular component size, regulation of monooxygenase activity, positive regulation of monooxygenase activity, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, regulation of protein localization, regulation of polysaccharide metabolic process, regulation of polysaccharide biosynthetic process, regulation of organic acid transport, negative regulation of organic acid transport, protein localization in organelle, negative regulation of kinase activity, positive regulation of kinase activity,cellular polysaccharide biosynthetic process, response to fluid shear stress, protein localization in nucleus, cellular protein localization, cellular carbohydrate biosynthetic process, growth, regulation of growth, regulation of locomotion,regulation of multicellular organism growth, positive regulation of multicellular organism growth, regulation of protein catabolic process, molting cycle, regulation of phosphorylation, homeostatic process, hair cycle, anagen, regulation of apoptosis, T cell homeostasis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death,positive regulation of catalytic activity, negative regulation of catalytic activity, regulation of carbohydrate biosynthetic process, regulation of ion transport, positive regulation of ion transport, regulation of MAPKKK cascade, negative regulation of MAPKKK cascade, response to peptide hormone stimulus, regulation of generation of precursor metabolites and energy, protein kinase B signaling cascade, regulation of kinase activity, glucan metabolic process,negative regulation of molecular function, positive regulation of molecular function, cellular polysaccharide metabolic process, nitrogen compound biosynthetic process, establishment of protein localization, regulation of nitric oxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, positive regulation of cell differentiation,regulation of fat cell differentiation, positive regulation of fat cell differentiation, positive regulation of glycogen biosynthetic process, positive regulation of protein catabolic process, positive regulation of cyclin-dependent protein kinase activity, positive regulation of cell cycle, negative regulation of cell size, positive regulation of cell size, negative regulation of lipid metabolic process, positive regulation of lipid metabolic process, regulation of protein kinase activity,positive regulation of protein kinase activity, positive regulation of proteolysis, regulation of survival gene product expression, positive regulation of carbohydrate metabolic process, negative regulation of fatty acid metabolic process,positive regulation of growth, nitric oxide metabolic process, regulation of fatty acid oxidation, negative regulation of fatty acid oxidation, regulation of glucose import, positive regulation of glucose import, regulation of JNK cascade,negative regulation of JNK cascade, protein amino acid autophosphorylation, positive regulation of lipid biosynthetic process, regulation of lipid biosynthetic process, intracellular transport, insulin-like growth factor receptor signaling pathway, negative regulation of response to stimulus, developmental growth, reproductive process in a multicellular organism, reproductive cellular process, hair follicle maturation, homeostasis of number of cells, regulation of lipid catabolic process, negative regulation of lipid catabolic process, regulation of nitric-oxide synthase activity, positive regulation of nitric-oxide synthase activity, positive regulation of transport, negative regulation of transport, positive regulation of developmental process, positive regulation of cellular component organization, nuclear transport, nuclear import, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process,positive regulation of multicellular organismal process, positive regulation of protein metabolic process, regulation of cell motion, interphase, interphase of mitotic cell cycle, regulation of transferase activity, regulation of oxidoreductase activity, positive regulation of transferase activity, negative regulation of transferase activity, positive regulation of oxidoreductase activity, regulation of cell cycle, negative regulation of cell death, response to UV-A, regulation of establishment of protein localization, lymphocyte apoptosis, T cell apoptosis, regulation of stress-activated protein kinase signaling pathway, negative regulation of stress-activated protein kinase signaling pathway, protein modification by small protein conjugation or removal, cellular macromolecule localization, regulation of cellular response to stress, regulation of establishment of protein localization to plasma membrane, positive regulation of establishment of protein localization to plasma membrane,
细胞定位： Cytoplasm . Nucleus . Cell membrane . Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). .
组织表达： Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
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