功能： DNA metabolic process, DNA repair, double-strand break repair, protein complex assembly, proteolysis, ubiquitin-dependent protein catabolic process, intracellular protein transport, ER to Golgi vesicle-mediated transport, apoptosis,activation of caspase activity, response to DNA damage stimulus, ER-nuclear signaling pathway, response to unfolded protein, protein localization, cell death, macromolecule catabolic process, response to organic substance, proteasomal protein catabolic process, regulation of cell death, positive regulation of peptidase activity, programmed cell death,protein transport, vesicle-mediated transport, death, protein ubiquitination, modification-dependent protein catabolic process, protein catabolic process, ER-associated protein catabolic process, endoplasmic reticulum unfolded protein response, retrograde protein transport, ER to cytosol, protein modification by small protein conjugation, cellular response to stress, cellular protein localization, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, positive regulation of catalytic activity,proteasomal ubiquitin-dependent protein catabolic process, positive regulation of caspase activity, regulation of caspase activity, modification-dependent macromolecule catabolic process, macromolecular complex subunit organization, positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process, establishment of protein localization, intracellular transport, Golgi vesicle transport, protein oligomerization, protein homooligomerization, regulation of hydrolase activity, positive regulation of hydrolase activity,proteolysis involved in cellular protein catabolic process, response to protein stimulus, regulation of peptidase activity,regulation of endopeptidase activity, macromolecular complex assembly, protein complex biogenesis, protein modification by small protein conjugation or removal, cellular macromolecule localization,
相关产品： YT4866,YP0480,KA4319C,KA1765C
细胞定位： Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Cytoplasm, Stress granule . Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787). Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377). Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668). Recruited to stalled replication forks via interaction with SPRTN (PubMed:23042605). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). Colocalizes with TIA1, ZFAND1 and G3BP1 in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment (PubMed:29804830). .
功能： DNA metabolic process, DNA repair, double-strand break repair, protein complex assembly, proteolysis, ubiquitin-dependent protein catabolic process, intracellular protein transport, ER to Golgi vesicle-mediated transport, apoptosis,activation of caspase activity, response to DNA damage stimulus, ER-nuclear signaling pathway, response to unfolded protein, protein localization, cell death, macromolecule catabolic process, response to organic substance, proteasomal protein catabolic process, regulation of cell death, positive regulation of peptidase activity, programmed cell death,protein transport, vesicle-mediated transport, death, protein ubiquitination, modification-dependent protein catabolic process, protein catabolic process, ER-associated protein catabolic process, endoplasmic reticulum unfolded protein response, retrograde protein transport, ER to cytosol, protein modification by small protein conjugation, cellular response to stress, cellular protein localization, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, positive regulation of catalytic activity,proteasomal ubiquitin-dependent protein catabolic process, positive regulation of caspase activity, regulation of caspase activity, modification-dependent macromolecule catabolic process, macromolecular complex subunit organization, positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process, establishment of protein localization, intracellular transport, Golgi vesicle transport, protein oligomerization, protein homooligomerization, regulation of hydrolase activity, positive regulation of hydrolase activity,proteolysis involved in cellular protein catabolic process, response to protein stimulus, regulation of peptidase activity,regulation of endopeptidase activity, macromolecular complex assembly, protein complex biogenesis, protein modification by small protein conjugation or removal, cellular macromolecule localization,
相关产品： YT4866,YP0480,KA4319C,KA1765C
细胞定位： Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Cytoplasm, Stress granule . Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787). Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787). Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377). Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668). Recruited to stalled replication forks via interaction with SPRTN (PubMed:23042605). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). Colocalizes with TIA1, ZFAND1 and G3BP1 in cytoplasmic stress granules (SGs) in response to arsenite-induced stress treatment (PubMed:29804830). .
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