功能： in utero embryonic development, regulation of cytokine production, negative regulation of cytokine production,placenta development, embryonic placenta development, response to molecule of bacterial origin, transcription,regulation of transcription, DNA-dependent, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, defense response, gamete generation, spermatogenesis, female pregnancy, negative regulation of cell proliferation, response to temperature stimulus, response to heat, response to bacterium, response to abiotic stimulus, embryonic development ending in birth or egg hatching, response to organic substance,phosphorylation, sexual reproduction, response to lipopolysaccharide, multicellular organism reproduction, regulation of tumor necrosis factor production, negative regulation of tumor necrosis factor production, regulation of growth,regulation of multicellular organism growth, positive regulation of multicellular organism growth, regulation of cell proliferation, chordate embryonic development, regulation of transcription, positive regulation of growth, male gamete generation, embryonic organ development, reproductive process in a multicellular organism, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process, regulation of RNA metabolic process, embryonic process involved in female pregnancy,
细胞定位： Nucleus . Cytoplasm . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . The monomeric form is cytoplasmic in unstressed cells (PubMed:8455624, PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells (PubMed:10413683, PubMed:10359787). Translocates in the nucleus upon heat shock (PubMed:8455624). Nucleocytoplasmic shuttling protein (PubMed:26159920). Colocalizes with IER5 in the nucleus (PubMed:27354066). Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:8455624, PubMed:26159920). Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock (PubMed:11447121, PubMed:11514557, PubMed:10359787, PubMed:25963659, PubMed:10747973, PubMed:24581496, PubMed:19229036). Colocalizes with SYMPK and SUMO1 in nSBs upon heat shock (PubMed:11447121, PubMed:12665592, PubMed:11514557, PubMed:14707147, PubMed:10359787). Colocalizes with PRKACA/PKA in the nucleus and nSBs upon heat shock (PubMed:21085490). Relocalizes from the nucleus to the cytoplasm during the attenuation and recovery phase period of the heat shock response (PubMed:26159920). Translocates in the cytoplasm in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Together with histone H2AX, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) (PubMed:26359349). Colocalizes with calcium-responsive transactivator SS18L1 at kinetochore region on the mitotic chromosomes (PubMed:18794143). Colocalizes with gamma tubulin at centrosome (PubMed:18794143). Localizes at spindle pole in metaphase (PubMed:18794143). Colocalizes with PLK1 at spindle poles during prometaphase (PubMed:18794143). .
功能： in utero embryonic development, regulation of cytokine production, negative regulation of cytokine production,placenta development, embryonic placenta development, response to molecule of bacterial origin, transcription,regulation of transcription, DNA-dependent, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, defense response, gamete generation, spermatogenesis, female pregnancy, negative regulation of cell proliferation, response to temperature stimulus, response to heat, response to bacterium, response to abiotic stimulus, embryonic development ending in birth or egg hatching, response to organic substance,phosphorylation, sexual reproduction, response to lipopolysaccharide, multicellular organism reproduction, regulation of tumor necrosis factor production, negative regulation of tumor necrosis factor production, regulation of growth,regulation of multicellular organism growth, positive regulation of multicellular organism growth, regulation of cell proliferation, chordate embryonic development, regulation of transcription, positive regulation of growth, male gamete generation, embryonic organ development, reproductive process in a multicellular organism, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process, regulation of RNA metabolic process, embryonic process involved in female pregnancy,
细胞定位： Nucleus . Cytoplasm . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . The monomeric form is cytoplasmic in unstressed cells (PubMed:8455624, PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells (PubMed:10413683, PubMed:10359787). Translocates in the nucleus upon heat shock (PubMed:8455624). Nucleocytoplasmic shuttling protein (PubMed:26159920). Colocalizes with IER5 in the nucleus (PubMed:27354066). Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:8455624, PubMed:26159920). Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock (PubMed:11447121, PubMed:11514557, PubMed:10359787, PubMed:25963659, PubMed:10747973, PubMed:24581496, PubMed:19229036). Colocalizes with SYMPK and SUMO1 in nSBs upon heat shock (PubMed:11447121, PubMed:12665592, PubMed:11514557, PubMed:14707147, PubMed:10359787). Colocalizes with PRKACA/PKA in the nucleus and nSBs upon heat shock (PubMed:21085490). Relocalizes from the nucleus to the cytoplasm during the attenuation and recovery phase period of the heat shock response (PubMed:26159920). Translocates in the cytoplasm in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Together with histone H2AX, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) (PubMed:26359349). Colocalizes with calcium-responsive transactivator SS18L1 at kinetochore region on the mitotic chromosomes (PubMed:18794143). Colocalizes with gamma tubulin at centrosome (PubMed:18794143). Localizes at spindle pole in metaphase (PubMed:18794143). Colocalizes with PLK1 at spindle poles during prometaphase (PubMed:18794143). .
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