其他名称： Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
功能： regulation of cyclin-dependent protein kinase activity, angiogenesis, blood vessel development, vasculature development, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, inositol metabolic process, protein amino acid dephosphorylation, phospholipid metabolic process, glycerophospholipid metabolic process, phosphorus metabolic process, phosphate metabolic process, apoptosis, induction of apoptosis, cell motion,negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, heart development, muscle organ development, aging, response to nutrient, behavior, learning or memory, memory, cell death, cell proliferation,negative regulation of cell proliferation, response to endogenous stimulus, response to hormone stimulus, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, negative regulation of signal transduction, response to extracellular stimulus, response to organic substance, response to inorganic substance,response to metal ion, response to zinc ion, posttranscriptional regulation of gene expression, regulation of protein kinase cascade, negative regulation of cell communication, negative regulation of protein kinase cascade, regulation of cell-substrate adhesion, negative regulation of cell-substrate adhesion, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, response to organic cyclic substance, striated muscle tissue development, death, dephosphorylation, cell migration, regulation of phosphate metabolic process,organophosphate metabolic process, polyol metabolic process, cell projection organization, regulation of endocytosis,regulation of cell adhesion, neuron differentiation, lipid modification, regulation of cell migration, negative regulation of cell migration, phosphoinositide metabolic process, neuron projection development, regulation of protein stability,response to nutrient levels, response to estradiol stimulus, response to ATP, response to monosaccharide stimulus,regulation of locomotion, negative regulation of locomotion, regulation of cell proliferation, regulation of phosphorylation, response to drug, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, endothelial cell migration, regulation of kinase activity, response to estrogen stimulus,regulation of cellular component biogenesis, response to ethanol, negative regulation of endocytosis, regulation of protein kinase activity, glycerolipid metabolic process, response to arsenic, phosphorylated carbohydrate dephosphorylation, phospholipid dephosphorylation, inositol phosphate dephosphorylation, phosphoinositide dephosphorylation, platelet-derived growth factor receptor signaling pathway, blood vessel morphogenesis, response to steroid hormone stimulus, neuron development, cardiac muscle tissue development, cell motility, regulation of phagocytosis, negative regulation of phagocytosis, neurological system process, cognition, negative regulation of transport, negative regulation of cellular component organization, regulation of phosphorus metabolic process,regulation of cell motion, negative regulation of cell motion, regulation of transferase activity, localization of cell,regulation of cell cycle, regulation of focal adhesion formation, negative regulation of focal adhesion formation,regulation of protein kinase B signaling cascade, negative regulation of protein kinase B signaling cascade, muscle tissue development, negative regulation of cell death, regulation of vesicle-mediated transport,
细胞定位： Cytoplasm . Nucleus . Nucleus, PML body . Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). .; [Isoform alpha]: Secreted . May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.
组织表达： Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
其他名称： Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
功能： regulation of cyclin-dependent protein kinase activity, angiogenesis, blood vessel development, vasculature development, regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, inositol metabolic process, protein amino acid dephosphorylation, phospholipid metabolic process, glycerophospholipid metabolic process, phosphorus metabolic process, phosphate metabolic process, apoptosis, induction of apoptosis, cell motion,negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, heart development, muscle organ development, aging, response to nutrient, behavior, learning or memory, memory, cell death, cell proliferation,negative regulation of cell proliferation, response to endogenous stimulus, response to hormone stimulus, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, negative regulation of signal transduction, response to extracellular stimulus, response to organic substance, response to inorganic substance,response to metal ion, response to zinc ion, posttranscriptional regulation of gene expression, regulation of protein kinase cascade, negative regulation of cell communication, negative regulation of protein kinase cascade, regulation of cell-substrate adhesion, negative regulation of cell-substrate adhesion, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, response to organic cyclic substance, striated muscle tissue development, death, dephosphorylation, cell migration, regulation of phosphate metabolic process,organophosphate metabolic process, polyol metabolic process, cell projection organization, regulation of endocytosis,regulation of cell adhesion, neuron differentiation, lipid modification, regulation of cell migration, negative regulation of cell migration, phosphoinositide metabolic process, neuron projection development, regulation of protein stability,response to nutrient levels, response to estradiol stimulus, response to ATP, response to monosaccharide stimulus,regulation of locomotion, negative regulation of locomotion, regulation of cell proliferation, regulation of phosphorylation, response to drug, regulation of apoptosis, positive regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of programmed cell death, endothelial cell migration, regulation of kinase activity, response to estrogen stimulus,regulation of cellular component biogenesis, response to ethanol, negative regulation of endocytosis, regulation of protein kinase activity, glycerolipid metabolic process, response to arsenic, phosphorylated carbohydrate dephosphorylation, phospholipid dephosphorylation, inositol phosphate dephosphorylation, phosphoinositide dephosphorylation, platelet-derived growth factor receptor signaling pathway, blood vessel morphogenesis, response to steroid hormone stimulus, neuron development, cardiac muscle tissue development, cell motility, regulation of phagocytosis, negative regulation of phagocytosis, neurological system process, cognition, negative regulation of transport, negative regulation of cellular component organization, regulation of phosphorus metabolic process,regulation of cell motion, negative regulation of cell motion, regulation of transferase activity, localization of cell,regulation of cell cycle, regulation of focal adhesion formation, negative regulation of focal adhesion formation,regulation of protein kinase B signaling cascade, negative regulation of protein kinase B signaling cascade, muscle tissue development, negative regulation of cell death, regulation of vesicle-mediated transport,
细胞定位： Cytoplasm . Nucleus . Nucleus, PML body . Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). .; [Isoform alpha]: Secreted . May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.
组织表达： Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
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