其他名称: Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)
功能: cell cycle checkpoint, G2/M transition of mitotic cell cycle, M phase of mitotic cell cycle, mitotic cell cycle, M phase,nuclear division, telomere maintenance, progressive alteration of chromatin during cell aging, replicative cell aging,progressive alteration of chromatin during replicative cell aging, age-dependent telomere shortening, DNA metabolic process, DNA replication, regulation of DNA replication, RNA-dependent DNA replication, chromatin organization,protein complex assembly, apoptosis, induction of apoptosis, activation of caspase activity, telomere maintenance via telomerase, cell cycle, mitosis, regulation of mitosis, mitotic cell cycle checkpoint, mitotic cell cycle spindle assembly checkpoint, regulation of mitotic cell cycle, aging, cell aging, negative regulation of DNA replication, cell death, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, regulation of cell cycle process, negative regulation of macromolecule metabolic process, positive regulation of organelle organization,negative regulation of organelle organization, telomere maintenance via telomere lengthening, telomere maintenance via telomere shortening, regulation of cell death, positive regulation of cell death, negative regulation of cell cycle process, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death, death,chromatin modification, cell cycle process, cell cycle phase, regulation of mitotic metaphase/anaphase transition,regulation of microtubule polymerization or depolymerization, positive regulation of microtubule polymerization or depolymerization, regulation of microtubule polymerization, positive regulation of microtubule polymerization, negative regulation of cellular biosynthetic process, positive regulation of protein complex assembly, spindle checkpoint,telomere organization, regulation of telomere maintenance, negative regulation of telomere maintenance, regulation of telomere maintenance via telomerase, negative regulation of telomere maintenance via telomerase, regulation of telomere maintenance via semi-conservative replication, negative regulation of telomere maintenance via semi-conservative replication, regulation of protein polymerization, positive regulation of protein polymerization, regulation of homeostatic process, negative regulation of homeostatic process, regulation of microtubule-based process,regulation of organelle organization, regulation of chromosome organization, homeostatic process, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, regulation of protein complex assembly, positive regulation of caspase activity, regulation of caspase activity, macromolecular complex subunit organization, regulation of cellular component biogenesis, negative regulation of molecular function, positive regulation of molecular function, regulation of transcription, negative regulation of cell cycle, positive regulation of cell cycle, negative regulation of mitosis, positive regulation of mitosis, negative regulation of mitotic metaphase/anaphase transition, positive regulation of mitotic cell cycle, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, organelle fission, regulation of DNA metabolic process,negative regulation of DNA metabolic process, negative regulation of cellular component organization, positive regulation of cellular component organization, negative regulation of nitrogen compound metabolic process, protein oligomerization, protein homooligomerization, chromosome organization, cell division, interphase, interphase of mitotic cell cycle, regulation of hydrolase activity, regulation of transferase activity, positive regulation of hydrolase activity,negative regulation of transferase activity, regulation of cytoskeleton organization, positive regulation of cytoskeleton organization, regulation of cell cycle, regulation of nuclear division, negative regulation of nuclear division, positive regulation of nuclear division, regulation of telomerase activity, negative regulation of telomerase activity, regulation of peptidase activity, regulation of endopeptidase activity, anatomical structure homeostasis, macromolecular complex assembly, protein complex biogenesis, regulation of microtubule cytoskeleton organization,
相关产品: YT4733,YP0400,KA1536C,KE1372,KE1709
细胞定位: Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
组织表达: Highly expressed and ubiquitous. Isoform Pin2 predominates.
其他名称: Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)
功能: cell cycle checkpoint, G2/M transition of mitotic cell cycle, M phase of mitotic cell cycle, mitotic cell cycle, M phase,nuclear division, telomere maintenance, progressive alteration of chromatin during cell aging, replicative cell aging,progressive alteration of chromatin during replicative cell aging, age-dependent telomere shortening, DNA metabolic process, DNA replication, regulation of DNA replication, RNA-dependent DNA replication, chromatin organization,protein complex assembly, apoptosis, induction of apoptosis, activation of caspase activity, telomere maintenance via telomerase, cell cycle, mitosis, regulation of mitosis, mitotic cell cycle checkpoint, mitotic cell cycle spindle assembly checkpoint, regulation of mitotic cell cycle, aging, cell aging, negative regulation of DNA replication, cell death, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, regulation of cell cycle process, negative regulation of macromolecule metabolic process, positive regulation of organelle organization,negative regulation of organelle organization, telomere maintenance via telomere lengthening, telomere maintenance via telomere shortening, regulation of cell death, positive regulation of cell death, negative regulation of cell cycle process, positive regulation of peptidase activity, programmed cell death, induction of programmed cell death, death,chromatin modification, cell cycle process, cell cycle phase, regulation of mitotic metaphase/anaphase transition,regulation of microtubule polymerization or depolymerization, positive regulation of microtubule polymerization or depolymerization, regulation of microtubule polymerization, positive regulation of microtubule polymerization, negative regulation of cellular biosynthetic process, positive regulation of protein complex assembly, spindle checkpoint,telomere organization, regulation of telomere maintenance, negative regulation of telomere maintenance, regulation of telomere maintenance via telomerase, negative regulation of telomere maintenance via telomerase, regulation of telomere maintenance via semi-conservative replication, negative regulation of telomere maintenance via semi-conservative replication, regulation of protein polymerization, positive regulation of protein polymerization, regulation of homeostatic process, negative regulation of homeostatic process, regulation of microtubule-based process,regulation of organelle organization, regulation of chromosome organization, homeostatic process, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, regulation of protein complex assembly, positive regulation of caspase activity, regulation of caspase activity, macromolecular complex subunit organization, regulation of cellular component biogenesis, negative regulation of molecular function, positive regulation of molecular function, regulation of transcription, negative regulation of cell cycle, positive regulation of cell cycle, negative regulation of mitosis, positive regulation of mitosis, negative regulation of mitotic metaphase/anaphase transition, positive regulation of mitotic cell cycle, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, organelle fission, regulation of DNA metabolic process,negative regulation of DNA metabolic process, negative regulation of cellular component organization, positive regulation of cellular component organization, negative regulation of nitrogen compound metabolic process, protein oligomerization, protein homooligomerization, chromosome organization, cell division, interphase, interphase of mitotic cell cycle, regulation of hydrolase activity, regulation of transferase activity, positive regulation of hydrolase activity,negative regulation of transferase activity, regulation of cytoskeleton organization, positive regulation of cytoskeleton organization, regulation of cell cycle, regulation of nuclear division, negative regulation of nuclear division, positive regulation of nuclear division, regulation of telomerase activity, negative regulation of telomerase activity, regulation of peptidase activity, regulation of endopeptidase activity, anatomical structure homeostasis, macromolecular complex assembly, protein complex biogenesis, regulation of microtubule cytoskeleton organization,
相关产品: YT4733,YP0400,KA1536C,KE1372,KE1709
细胞定位: Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
组织表达: Highly expressed and ubiquitous. Isoform Pin2 predominates.