其他名称： Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)
功能： cell cycle checkpoint, DNA damage checkpoint, M phase, telomere maintenance, in utero embryonic development, cell activation, blastocyst development, blastocyst growth, somatic diversification of immune receptors, somatic recombination of immunoglobulin genes during immune response, somatic diversification of immunoglobulins during immune response, adaptive immune response, immune effector process, immunoglobulin production, immunoglobulin production during immune response, production of molecular mediator of immune response, leukocyte mediated immunity, lymphocyte mediated immunity, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, immune system development, somatic diversification of immune receptors via germline recombination within a single locus, DNA metabolic process, regulation of DNA replication, DNA repair, double-strand break repair, DNA recombination, immune response, response to DNA damage stimulus, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, mitotic cell cycle G2/M transition DNA damage checkpoint, meiosis, intracellular signaling cascade, regulation of mitotic cell cycle, cell proliferation, positive regulation of cell proliferation, embryonic development ending in birth or egg hatching, immunoglobulin mediated immune response, somatic cell DNA recombination, somatic diversification of immunoglobulins, somatic recombination of immunoglobulin gene segments, B cell mediated immunity, cell cycle process, cell cycle phase, regulation of DNA replication initiation, DNA damage response, signal transduction by p53 class mediator, DNA integrity checkpoint, G2/M transition DNA damage checkpoint, G1/S transition checkpoint, G2/M transition checkpoint, telomere organization,cellular response to stress, growth, B cell activation, regulation of cell proliferation, response to drug, homeostatic process, DNA damage response, signal transduction, chordate embryonic development, isotype switching, leukocyte activation, negative regulation of cell differentiation, regulation of neuron differentiation, negative regulation of neuron differentiation, lymphocyte activation, regulation of fibroblast proliferation, developmental growth, regulation of neurogenesis, neurological system process, neuromuscular process controlling balance, neuromuscular process,regulation of DNA metabolic process, chromosome organization, meiotic cell cycle, M phase of meiotic cell cycle,regulation of cell cycle, regulation of nervous system development, anatomical structure homeostasis, regulation of cell development,
细胞定位： Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). .
组织表达： Ubiquitous (PubMed:9590180). Expressed at high levels in testis (PubMed:9590180).
其他名称： Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)
功能： cell cycle checkpoint, DNA damage checkpoint, M phase, telomere maintenance, in utero embryonic development, cell activation, blastocyst development, blastocyst growth, somatic diversification of immune receptors, somatic recombination of immunoglobulin genes during immune response, somatic diversification of immunoglobulins during immune response, adaptive immune response, immune effector process, immunoglobulin production, immunoglobulin production during immune response, production of molecular mediator of immune response, leukocyte mediated immunity, lymphocyte mediated immunity, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, immune system development, somatic diversification of immune receptors via germline recombination within a single locus, DNA metabolic process, regulation of DNA replication, DNA repair, double-strand break repair, DNA recombination, immune response, response to DNA damage stimulus, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, mitotic cell cycle G2/M transition DNA damage checkpoint, meiosis, intracellular signaling cascade, regulation of mitotic cell cycle, cell proliferation, positive regulation of cell proliferation, embryonic development ending in birth or egg hatching, immunoglobulin mediated immune response, somatic cell DNA recombination, somatic diversification of immunoglobulins, somatic recombination of immunoglobulin gene segments, B cell mediated immunity, cell cycle process, cell cycle phase, regulation of DNA replication initiation, DNA damage response, signal transduction by p53 class mediator, DNA integrity checkpoint, G2/M transition DNA damage checkpoint, G1/S transition checkpoint, G2/M transition checkpoint, telomere organization,cellular response to stress, growth, B cell activation, regulation of cell proliferation, response to drug, homeostatic process, DNA damage response, signal transduction, chordate embryonic development, isotype switching, leukocyte activation, negative regulation of cell differentiation, regulation of neuron differentiation, negative regulation of neuron differentiation, lymphocyte activation, regulation of fibroblast proliferation, developmental growth, regulation of neurogenesis, neurological system process, neuromuscular process controlling balance, neuromuscular process,regulation of DNA metabolic process, chromosome organization, meiotic cell cycle, M phase of meiotic cell cycle,regulation of cell cycle, regulation of nervous system development, anatomical structure homeostasis, regulation of cell development,
细胞定位： Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). .
组织表达： Ubiquitous (PubMed:9590180). Expressed at high levels in testis (PubMed:9590180).
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