功能： temperature homeostasis, tissue homeostasis, regulation of systemic arterial blood pressure by norepinephrine-epinephrine, response to dietary excess, diet induced thermogenesis, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, regulation of sodium ion transport, desensitization of G-protein coupled receptor protein signaling pathway, desensitization of G-protein coupled receptor protein signaling pathway by arrestin, circulatory system process, vascular process in circulatory system, regulation of systemic arterial blood pressure mediated by a chemical signal, regulation of systemic arterial blood pressure, negative regulation of systemic arterial blood pressure, regulation of nucleotide metabolic process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly, endocytosis,receptor-mediated endocytosis, regulation of muscle contraction, regulation of smooth muscle contraction, vacuolar transport, lysosomal transport, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, activation of transmembrane receptor protein tyrosine kinase activity, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, G-protein signaling, coupled to cAMP nucleotide second messenger,activation of adenylate cyclase activity by G-protein signaling pathway, activation of adenylate cyclase activity,intracellular signaling cascade, blood circulation, regulation of heart contraction, regulation of blood pressure,regulation of G-protein coupled receptor protein signaling pathway, positive regulation of cell proliferation, endosome to lysosome transport, response to temperature stimulus, response to cold, response to abiotic stimulus, positive regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of signal transduction, membrane invagination, positive regulation of macromolecule biosynthetic process, regulation of adenylate cyclase activity involved in G-protein signaling, positive regulation of adenylate cyclase activity by G-protein signaling pathway, positive regulation of macromolecule metabolic process, regulation of protein kinase cascade,positive regulation of gene expression, positive regulation of cell communication, negative regulation of cell communication, positive regulation of protein kinase cascade, positive regulation of sodium ion transport, regulation of cell death, positive regulation of cell death, regulation of metal ion transport, membrane organization, vesicle-mediated transport, endosome transport, regulation of striated muscle tissue development, regulation of phosphate metabolic process, second-messenger-mediated signaling, cAMP-mediated signaling, cyclic-nucleotide-mediated signaling, adaptation of signaling pathway, regulation of transmembrane transporter activity, regulation of ossification, negative regulation of ossification, regulation of bone mineralization, positive regulation of bone mineralization, regulation of cyclic nucleotide metabolic process, regulation of cyclic nucleotide biosynthetic process,regulation of nucleotide biosynthetic process, regulation of cAMP metabolic process, regulation of cAMP biosynthetic process, regulation of cyclase activity, positive regulation of cyclase activity, positive regulation of cellular biosynthetic process, negative regulation of defense response, regulation of neurological system process, heat generation,negative regulation of protein binding, regulation of response to external stimulus, negative regulation of response to external stimulus, activation of protein kinase activity, regulation of transporter activity, negative regulation of transporter activity, regulation of ion transmembrane transporter activity, negative regulation of ion transmembrane transporter activity, positive regulation of kinase activity, cellular macromolecular complex subunit organization,cellular macromolecular complex assembly, regulation of transmembrane transport, regulation of ion transmembrane transport, regulation of tube size, regulation of growth, regulation of multicellular organism growth, negative regulation of multicellular organism growth, regulation of cell proliferation, vasodilation, regulation of vasodilation,regulation of phosphorylation, homeostatic process, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, regulation of potassium ion transport, positive regulation of potassium ion transport, regulation of ion transport, positive regulation of ion transport, negative regulation of ion transport, regulation of protein binding,regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, regulation of kinase activity, cellular protein complex assembly, macromolecular complex subunit organization, regulation of system process, negative regulation of molecular function, positive regulation of molecular function, regulation of multicellular organismal metabolic process,positive regulation of multicellular organismal metabolic process, fat cell differentiation, regulation of transcription,bone resorption, negative regulation of G-protein coupled receptor protein signaling pathway, regulation of adenylate cyclase activity, positive regulation of adenylate cyclase activity, negative regulation of blood pressure, positive regulation of ossification, positive regulation of heart contraction, positive regulation of striated muscle development,regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of vasodilation, negative regulation of growth, positive regulation of growth,negative regulation of muscle contraction, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, negative regulation of smooth muscle contraction, bone remodeling, intracellular transport, negative regulation of response to stimulus, regulation of skeletal muscle growth, positive regulation of skeletal muscle growth,regulation of muscle development, positive regulation of muscle development, regulation of developmental growth,positive regulation of developmental growth, regulation of skeletal muscle tissue development, positive regulation of skeletal muscle tissue development, tissue remodeling, multicellular organismal homeostasis, regulation of inflammatory response, negative regulation of inflammatory response, brown fat cell differentiation, regulation of blood vessel size, positive regulation of transport, negative regulation of transport, positive regulation of developmental process, regulation of binding, negative regulation of binding, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of multicellular organismal process,negative regulation of multicellular organismal process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of transferase activity, regulation of lyase activity, positive regulation of transferase activity, positive regulation of lyase activity, regulation of calcium ion transport, regulation of calcium ion transport via voltage-gated calcium channel activity, negative regulation of calcium ion transport, negative regulation of calcium ion transport via voltage-gated calcium channel activity, regulation of sensory perception of pain, regulation of sensory perception, anatomical structure homeostasis, macromolecular complex assembly, regulation of biomineral formation,positive regulation of biomineral formation, protein complex biogenesis,
细胞定位： Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .
功能： temperature homeostasis, tissue homeostasis, regulation of systemic arterial blood pressure by norepinephrine-epinephrine, response to dietary excess, diet induced thermogenesis, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, regulation of sodium ion transport, desensitization of G-protein coupled receptor protein signaling pathway, desensitization of G-protein coupled receptor protein signaling pathway by arrestin, circulatory system process, vascular process in circulatory system, regulation of systemic arterial blood pressure mediated by a chemical signal, regulation of systemic arterial blood pressure, negative regulation of systemic arterial blood pressure, regulation of nucleotide metabolic process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly, endocytosis,receptor-mediated endocytosis, regulation of muscle contraction, regulation of smooth muscle contraction, vacuolar transport, lysosomal transport, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, activation of transmembrane receptor protein tyrosine kinase activity, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, G-protein signaling, coupled to cAMP nucleotide second messenger,activation of adenylate cyclase activity by G-protein signaling pathway, activation of adenylate cyclase activity,intracellular signaling cascade, blood circulation, regulation of heart contraction, regulation of blood pressure,regulation of G-protein coupled receptor protein signaling pathway, positive regulation of cell proliferation, endosome to lysosome transport, response to temperature stimulus, response to cold, response to abiotic stimulus, positive regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of signal transduction, membrane invagination, positive regulation of macromolecule biosynthetic process, regulation of adenylate cyclase activity involved in G-protein signaling, positive regulation of adenylate cyclase activity by G-protein signaling pathway, positive regulation of macromolecule metabolic process, regulation of protein kinase cascade,positive regulation of gene expression, positive regulation of cell communication, negative regulation of cell communication, positive regulation of protein kinase cascade, positive regulation of sodium ion transport, regulation of cell death, positive regulation of cell death, regulation of metal ion transport, membrane organization, vesicle-mediated transport, endosome transport, regulation of striated muscle tissue development, regulation of phosphate metabolic process, second-messenger-mediated signaling, cAMP-mediated signaling, cyclic-nucleotide-mediated signaling, adaptation of signaling pathway, regulation of transmembrane transporter activity, regulation of ossification, negative regulation of ossification, regulation of bone mineralization, positive regulation of bone mineralization, regulation of cyclic nucleotide metabolic process, regulation of cyclic nucleotide biosynthetic process,regulation of nucleotide biosynthetic process, regulation of cAMP metabolic process, regulation of cAMP biosynthetic process, regulation of cyclase activity, positive regulation of cyclase activity, positive regulation of cellular biosynthetic process, negative regulation of defense response, regulation of neurological system process, heat generation,negative regulation of protein binding, regulation of response to external stimulus, negative regulation of response to external stimulus, activation of protein kinase activity, regulation of transporter activity, negative regulation of transporter activity, regulation of ion transmembrane transporter activity, negative regulation of ion transmembrane transporter activity, positive regulation of kinase activity, cellular macromolecular complex subunit organization,cellular macromolecular complex assembly, regulation of transmembrane transport, regulation of ion transmembrane transport, regulation of tube size, regulation of growth, regulation of multicellular organism growth, negative regulation of multicellular organism growth, regulation of cell proliferation, vasodilation, regulation of vasodilation,regulation of phosphorylation, homeostatic process, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, regulation of potassium ion transport, positive regulation of potassium ion transport, regulation of ion transport, positive regulation of ion transport, negative regulation of ion transport, regulation of protein binding,regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, regulation of kinase activity, cellular protein complex assembly, macromolecular complex subunit organization, regulation of system process, negative regulation of molecular function, positive regulation of molecular function, regulation of multicellular organismal metabolic process,positive regulation of multicellular organismal metabolic process, fat cell differentiation, regulation of transcription,bone resorption, negative regulation of G-protein coupled receptor protein signaling pathway, regulation of adenylate cyclase activity, positive regulation of adenylate cyclase activity, negative regulation of blood pressure, positive regulation of ossification, positive regulation of heart contraction, positive regulation of striated muscle development,regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of vasodilation, negative regulation of growth, positive regulation of growth,negative regulation of muscle contraction, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, negative regulation of smooth muscle contraction, bone remodeling, intracellular transport, negative regulation of response to stimulus, regulation of skeletal muscle growth, positive regulation of skeletal muscle growth,regulation of muscle development, positive regulation of muscle development, regulation of developmental growth,positive regulation of developmental growth, regulation of skeletal muscle tissue development, positive regulation of skeletal muscle tissue development, tissue remodeling, multicellular organismal homeostasis, regulation of inflammatory response, negative regulation of inflammatory response, brown fat cell differentiation, regulation of blood vessel size, positive regulation of transport, negative regulation of transport, positive regulation of developmental process, regulation of binding, negative regulation of binding, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of multicellular organismal process,negative regulation of multicellular organismal process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of transferase activity, regulation of lyase activity, positive regulation of transferase activity, positive regulation of lyase activity, regulation of calcium ion transport, regulation of calcium ion transport via voltage-gated calcium channel activity, negative regulation of calcium ion transport, negative regulation of calcium ion transport via voltage-gated calcium channel activity, regulation of sensory perception of pain, regulation of sensory perception, anatomical structure homeostasis, macromolecular complex assembly, regulation of biomineral formation,positive regulation of biomineral formation, protein complex biogenesis,
细胞定位： Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325). Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). .
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