其他名称： Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
功能： MAPKKK cascade, microtubule cytoskeleton organization, response to reactive oxygen species, regulation of cell growth, eye development, muscle system process, monosaccharide metabolic process, glucose metabolic process,protein folding, protein complex assembly, oxygen and reactive oxygen species metabolic process, anti-apoptosis,muscle contraction, response to oxidative stress, cytoskeleton organization, microtubule-based process, intracellular signaling cascade, protein kinase cascade, sensory organ development, muscle organ development, aging, regulation of cell size, response to temperature stimulus, response to heat, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to inorganic substance, regulation of cell death, hexose metabolic process, negative regulation of cell growth, stress-activated protein kinase signaling pathway, microtubule polymerization or depolymerization, response to estradiol stimulus,regulation of intracellular transport, negative regulation of intracellular transport, regulation of cellular component size, cellular response to stress, regulation of growth, response to hydrogen peroxide, regulation of apoptosis,camera-type eye development, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, response to estrogen stimulus, macromolecular complex subunit organization,negative regulation of cell size, negative regulation of growth, response to steroid hormone stimulus, negative regulation of transport, protein oligomerization, protein homooligomerization, stress-activated MAPK cascade,regulation of cellular localization, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,
细胞定位： Cytoplasm . Nucleus . Secreted . Lysosome . Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
组织表达： Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373).
其他名称： Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
功能： MAPKKK cascade, microtubule cytoskeleton organization, response to reactive oxygen species, regulation of cell growth, eye development, muscle system process, monosaccharide metabolic process, glucose metabolic process,protein folding, protein complex assembly, oxygen and reactive oxygen species metabolic process, anti-apoptosis,muscle contraction, response to oxidative stress, cytoskeleton organization, microtubule-based process, intracellular signaling cascade, protein kinase cascade, sensory organ development, muscle organ development, aging, regulation of cell size, response to temperature stimulus, response to heat, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to inorganic substance, regulation of cell death, hexose metabolic process, negative regulation of cell growth, stress-activated protein kinase signaling pathway, microtubule polymerization or depolymerization, response to estradiol stimulus,regulation of intracellular transport, negative regulation of intracellular transport, regulation of cellular component size, cellular response to stress, regulation of growth, response to hydrogen peroxide, regulation of apoptosis,camera-type eye development, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, response to estrogen stimulus, macromolecular complex subunit organization,negative regulation of cell size, negative regulation of growth, response to steroid hormone stimulus, negative regulation of transport, protein oligomerization, protein homooligomerization, stress-activated MAPK cascade,regulation of cellular localization, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,
细胞定位： Cytoplasm . Nucleus . Secreted . Lysosome . Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
组织表达： Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373).
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