Phospho PAK1/2/3 (S144/141/139) Cell-Based Colorimetric ELISA Kit

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商品货号： PLA000320

￥600元

规格：

40μL 100μL 200μL

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MSDS

说明书

商品描述

发货日期： 14
基因名称： PAK1/PAK2/PAK3
Human_swiss_prot_no： Q13153/Q13177/O75914
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13153/entry
储存： 2-8°C/6 months
说明书： KA1318C.pdf
功能： MAPKKK cascade, regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, ER-nuclear signaling pathway, cytoskeleton organization,intracellular signaling cascade, protein kinase cascade, cell death, regulation of protein kinase cascade, programmed cell death, death, phosphorylation, regulation of phosphate metabolic process, regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of kinase activity, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of MAPKKK cascade, regulation of JUN kinase activity, positive regulation of JUN kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity,positive regulation of protein kinase activity, regulation of JNK cascade, protein amino acid autophosphorylation,regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,
相关产品： YT3579,YT3578,YP0961,YP0667,KA1318C
细胞定位： Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). .
组织表达： Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).
科研货号： PLA000320

Phospho PAK1/2/3 (S144/141/139) Cell-Based Colorimetric ELISA Kit

Catalog No PLA000320

Product information

发货日期： 14
基因名称： PAK1/PAK2/PAK3
Human_swiss_prot_no： Q13153/Q13177/O75914
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13153/entry
储存： 2-8°C/6 months
说明书： KA1318C.pdf
功能： MAPKKK cascade, regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, ER-nuclear signaling pathway, cytoskeleton organization,intracellular signaling cascade, protein kinase cascade, cell death, regulation of protein kinase cascade, programmed cell death, death, phosphorylation, regulation of phosphate metabolic process, regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of kinase activity, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of MAPKKK cascade, regulation of JUN kinase activity, positive regulation of JUN kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity,positive regulation of protein kinase activity, regulation of JNK cascade, protein amino acid autophosphorylation,regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,
相关产品： YT3579,YT3578,YP0961,YP0667,KA1318C
细胞定位： Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). .
组织表达： Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).
科研货号： PLA000320

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