功能: cytokine production, response to molecule of bacterial origin, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, transcription from RNA polymerase II promoter, cell surface receptor linked signal transduction, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, response to virus, response to bacterium, response to organic substance, lipopolysaccharide-mediated signaling pathway,response to lipopolysaccharide, type I interferon production, RNA biosynthetic process, cytokine biosynthetic process,cytokine metabolic process, response to exogenous dsRNA, response to dsRNA, type I interferon biosynthetic process,regulation of transcription, regulation of RNA metabolic process,
细胞定位: Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .
组织表达: Expressed constitutively in a variety of tissues.
功能: cytokine production, response to molecule of bacterial origin, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, transcription from RNA polymerase II promoter, cell surface receptor linked signal transduction, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, response to virus, response to bacterium, response to organic substance, lipopolysaccharide-mediated signaling pathway,response to lipopolysaccharide, type I interferon production, RNA biosynthetic process, cytokine biosynthetic process,cytokine metabolic process, response to exogenous dsRNA, response to dsRNA, type I interferon biosynthetic process,regulation of transcription, regulation of RNA metabolic process,
细胞定位: Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .
组织表达: Expressed constitutively in a variety of tissues.