其他名称： Fanconi anemia group D2 protein (Protein FACD2)
功能： M phase, DNA metabolic process, DNA repair, response to DNA damage stimulus, cell cycle, meiosis, meiosis I,synapsis, gamete generation, response to radiation, response to abiotic stimulus, response to ionizing radiation,response to gamma radiation, sexual reproduction, cell cycle process, cell cycle phase, multicellular organism reproduction, cellular response to stress, reproductive process in a multicellular organism, chromosome organization,meiotic cell cycle, M phase of meiotic cell cycle, chromosome organization involved in meiosis,
相关产品： YT1675,YP0630,KA4095C,KA1250C
细胞定位： Nucleus . Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks.
组织表达： Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.
其他名称： Fanconi anemia group D2 protein (Protein FACD2)
功能： M phase, DNA metabolic process, DNA repair, response to DNA damage stimulus, cell cycle, meiosis, meiosis I,synapsis, gamete generation, response to radiation, response to abiotic stimulus, response to ionizing radiation,response to gamma radiation, sexual reproduction, cell cycle process, cell cycle phase, multicellular organism reproduction, cellular response to stress, reproductive process in a multicellular organism, chromosome organization,meiotic cell cycle, M phase of meiotic cell cycle, chromosome organization involved in meiosis,
相关产品： YT1675,YP0630,KA4095C,KA1250C
细胞定位： Nucleus . Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks.
组织表达： Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.
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