其他名称： SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
功能： MAPKKK cascade, activation of MAPK activity, regulation of DNA replication, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway,epidermal growth factor receptor signaling pathway, regulation of epidermal growth factor receptor activity,intracellular signaling cascade, protein kinase cascade, small GTPase mediated signal transduction, Ras protein signal transduction, positive regulation of cell proliferation, insulin receptor signaling pathway, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, response to organic substance,regulation of receptor activity, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, phosphorylation, regulation of phosphate metabolic process, positive regulation of cellular biosynthetic process, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, positive regulation of kinase activity, regulation of growth, regulation of epidermal growth factor receptor signaling pathway, regulation of cell proliferation, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, response to peptide hormone stimulus, regulation of kinase activity, positive regulation of molecular function, positive regulation of DNA replication, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity,
细胞定位： Cytoplasm.; [Isoform p46Shc]: Mitochondrion matrix . Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; [Isoform p66Shc]: Mitochondrion . In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. .
组织表达： Widely expressed. Expressed in neural stem cells but absent in mature neurons.
其他名称： SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
功能： MAPKKK cascade, activation of MAPK activity, regulation of DNA replication, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway,epidermal growth factor receptor signaling pathway, regulation of epidermal growth factor receptor activity,intracellular signaling cascade, protein kinase cascade, small GTPase mediated signal transduction, Ras protein signal transduction, positive regulation of cell proliferation, insulin receptor signaling pathway, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, response to organic substance,regulation of receptor activity, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, phosphorylation, regulation of phosphate metabolic process, positive regulation of cellular biosynthetic process, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, positive regulation of kinase activity, regulation of growth, regulation of epidermal growth factor receptor signaling pathway, regulation of cell proliferation, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, response to peptide hormone stimulus, regulation of kinase activity, positive regulation of molecular function, positive regulation of DNA replication, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity,
细胞定位： Cytoplasm.; [Isoform p46Shc]: Mitochondrion matrix . Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; [Isoform p66Shc]: Mitochondrion . In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. .
组织表达： Widely expressed. Expressed in neural stem cells but absent in mature neurons.
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