功能： G2 phase of mitotic cell cycle, mitotic cell cycle, cell morphogenesis, cell morphogenesis involved in differentiation,suckling behavior, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, mRNA polyadenylation, RNA processing, mRNA processing, regulation of translation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, cellular copper ion homeostasis, endocytosis, apoptosis,induction of apoptosis, cell motion, microtubule-based process, microtubule-based movement, cell cycle, cell adhesion,cell surface receptor linked signal transduction, regulation of epidermal growth factor receptor activity, glutamate signaling pathway, Notch signaling pathway, cell-cell signaling, synaptic transmission, regulation of mitotic cell cycle,axonogenesis, axon guidance, synaptogenesis, muscle organ development, skeletal muscle tissue development,neuromuscular junction development, behavior, learning or memory, learning, mating behavior, mating, locomotory behavior, feeding behavior, visual behavior, cell recognition, neuron recognition, axon cargo transport, cell death,adult locomotory behavior, regulation of cell size, visual learning, response to radiation, response to light stimulus,response to abiotic stimulus, positive regulation of biosynthetic process, membrane invagination, regulation of receptor activity, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, positive regulation of gene expression,regulation of cell death, positive regulation of cell death, microtubule-based transport, programmed cell death,induction of programmed cell death, striated muscle tissue development, membrane organization, cell growth, mRNA metabolic process, vesicle-mediated transport, axon choice point recognition, axon midline choice point recognition,death, phosphorylation, neuron remodeling, dendrite development, reproductive behavior, regulation of phosphate metabolic process, transmission of nerve impulse, cellular homeostasis, developmental maturation, cell cycle process,cell cycle phase, biological adhesion, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis,cell projection organization, neuron differentiation, extracellular matrix organization, adult behavior, cytoskeleton-dependent intracellular transport, forebrain development, RNA 3'-end processing, mRNA 3'-end processing, neuron projection development, positive regulation of cellular biosynthetic process, regulation of cellular protein metabolic process, endoplasmic reticulum calcium ion homeostasis, regulation of cellular component size, cellular component morphogenesis, cell part morphogenesis, ionotropic glutamate receptor signaling pathway, growth, regulation of growth, regulation of multicellular organism growth, regulation of epidermal growth factor receptor signaling pathway,regulation of phosphorylation, neuron maturation, homeostatic process, muscle cell differentiation, regulation of apoptosis, extracellular structure organization, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, regulation of kinase activity, RNA polyadenylation, regulation of transcription, positive regulation of cell cycle, regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of mitotic cell cycle, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, intracellular transport, cell maturation, developmental cell growth, developmental growth,neuron development, cell morphogenesis involved in neuron differentiation, collateral sprouting, collateral sprouting in the absence of injury, skeletal muscle fiber development, muscle fiber development, neuron projection morphogenesis, cell projection morphogenesis, chemical homeostasis, ion homeostasis, regulation of synapse structure and activity, synapse organization, neurological system process, neuromuscular process controlling balance,cognition, neuromuscular process, synaptic growth at neuromuscular junction, striated muscle cell differentiation,positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, G2 phase, interphase, interphase of mitotic cell cycle, regulation of transferase activity, neuron apoptosis, smooth endoplasmic reticulum calcium ion homeostasis,behavioral interaction between organisms, regulation of cell cycle, muscle cell development, striated muscle cell development, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, copper ion homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, muscle tissue development, skeletal muscle organ development,
相关产品： YT5773,YT5754,YT0226,YP0855,KA1162C
细胞定位： Cell membrane ; Single-pass type I membrane protein . Membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Membrane, clathrin-coated pit . Early endosome . Cytoplasmic vesicle . Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body (PubMed:10341243). Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Colocalizes with SORL1 in a vesicular pattern in cytoplasm and perinuclear regions. .; [C83]: Endoplasmic reticulum . Golgi apparatus . Early endosome .; [C99]: Early endosome .; [Soluble APP-beta]: Secreted .; [Amyloid-beta protein 42]: Cell surface. Associates with FPR2 at the cell surface and the complex is then rapidly internalized. .; [Gamma-secretase C-terminal fragment 59]: Nucleus . Cytoplasm . Located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65) (PubMed:11544248). In dopaminergic neurons, the phosphorylated Thr-743 form is localized to the nucleus (By similarity). .
组织表达： Expressed in the brain and in cerebrospinal fluid (at protein level) (PubMed:2649245). Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.
功能： G2 phase of mitotic cell cycle, mitotic cell cycle, cell morphogenesis, cell morphogenesis involved in differentiation,suckling behavior, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, mRNA polyadenylation, RNA processing, mRNA processing, regulation of translation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, cellular copper ion homeostasis, endocytosis, apoptosis,induction of apoptosis, cell motion, microtubule-based process, microtubule-based movement, cell cycle, cell adhesion,cell surface receptor linked signal transduction, regulation of epidermal growth factor receptor activity, glutamate signaling pathway, Notch signaling pathway, cell-cell signaling, synaptic transmission, regulation of mitotic cell cycle,axonogenesis, axon guidance, synaptogenesis, muscle organ development, skeletal muscle tissue development,neuromuscular junction development, behavior, learning or memory, learning, mating behavior, mating, locomotory behavior, feeding behavior, visual behavior, cell recognition, neuron recognition, axon cargo transport, cell death,adult locomotory behavior, regulation of cell size, visual learning, response to radiation, response to light stimulus,response to abiotic stimulus, positive regulation of biosynthetic process, membrane invagination, regulation of receptor activity, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, positive regulation of gene expression,regulation of cell death, positive regulation of cell death, microtubule-based transport, programmed cell death,induction of programmed cell death, striated muscle tissue development, membrane organization, cell growth, mRNA metabolic process, vesicle-mediated transport, axon choice point recognition, axon midline choice point recognition,death, phosphorylation, neuron remodeling, dendrite development, reproductive behavior, regulation of phosphate metabolic process, transmission of nerve impulse, cellular homeostasis, developmental maturation, cell cycle process,cell cycle phase, biological adhesion, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis,cell projection organization, neuron differentiation, extracellular matrix organization, adult behavior, cytoskeleton-dependent intracellular transport, forebrain development, RNA 3'-end processing, mRNA 3'-end processing, neuron projection development, positive regulation of cellular biosynthetic process, regulation of cellular protein metabolic process, endoplasmic reticulum calcium ion homeostasis, regulation of cellular component size, cellular component morphogenesis, cell part morphogenesis, ionotropic glutamate receptor signaling pathway, growth, regulation of growth, regulation of multicellular organism growth, regulation of epidermal growth factor receptor signaling pathway,regulation of phosphorylation, neuron maturation, homeostatic process, muscle cell differentiation, regulation of apoptosis, extracellular structure organization, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, regulation of kinase activity, RNA polyadenylation, regulation of transcription, positive regulation of cell cycle, regulation of protein kinase activity, positive regulation of transcription, DNA-dependent, positive regulation of mitotic cell cycle, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, intracellular transport, cell maturation, developmental cell growth, developmental growth,neuron development, cell morphogenesis involved in neuron differentiation, collateral sprouting, collateral sprouting in the absence of injury, skeletal muscle fiber development, muscle fiber development, neuron projection morphogenesis, cell projection morphogenesis, chemical homeostasis, ion homeostasis, regulation of synapse structure and activity, synapse organization, neurological system process, neuromuscular process controlling balance,cognition, neuromuscular process, synaptic growth at neuromuscular junction, striated muscle cell differentiation,positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, G2 phase, interphase, interphase of mitotic cell cycle, regulation of transferase activity, neuron apoptosis, smooth endoplasmic reticulum calcium ion homeostasis,behavioral interaction between organisms, regulation of cell cycle, muscle cell development, striated muscle cell development, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, copper ion homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, muscle tissue development, skeletal muscle organ development,
相关产品： YT5773,YT5754,YT0226,YP0855,KA1162C
细胞定位： Cell membrane ; Single-pass type I membrane protein . Membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Membrane, clathrin-coated pit . Early endosome . Cytoplasmic vesicle . Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proportion is present at the cell membrane; most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body (PubMed:10341243). Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment. Associates with GPC1 in perinuclear compartments. Colocalizes with SORL1 in a vesicular pattern in cytoplasm and perinuclear regions. .; [C83]: Endoplasmic reticulum . Golgi apparatus . Early endosome .; [C99]: Early endosome .; [Soluble APP-beta]: Secreted .; [Amyloid-beta protein 42]: Cell surface. Associates with FPR2 at the cell surface and the complex is then rapidly internalized. .; [Gamma-secretase C-terminal fragment 59]: Nucleus . Cytoplasm . Located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65) (PubMed:11544248). In dopaminergic neurons, the phosphorylated Thr-743 form is localized to the nucleus (By similarity). .
组织表达： Expressed in the brain and in cerebrospinal fluid (at protein level) (PubMed:2649245). Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.
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