功能： cell cycle checkpoint, DNA damage checkpoint, regulation of cyclin-dependent protein kinase activity, G2/M transition of mitotic cell cycle, mitotic cell cycle, M phase, DNA metabolic process, DNA replication, DNA repair, DNA recombination,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, cell cycle, meiosis, meiosis I, reciprocal meiotic recombination, intracellular signaling cascade,gamete generation, negative regulation of cell proliferation, phosphorylation, regulation of phosphate metabolic process, sexual reproduction, cell cycle process, cell cycle phase, DNA integrity checkpoint, multicellular organism reproduction, cellular response to stress, regulation of cell proliferation, regulation of phosphorylation, DNA damage response, signal transduction, regulation of kinase activity, regulation of protein kinase activity, reproductive process in a multicellular organism, regulation of phosphorus metabolic process, meiotic cell cycle, interphase, M phase of meiotic cell cycle, interphase of mitotic cell cycle, regulation of transferase activity, regulation of cell cycle,
细胞定位： Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). .
组织表达： Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon.
功能： cell cycle checkpoint, DNA damage checkpoint, regulation of cyclin-dependent protein kinase activity, G2/M transition of mitotic cell cycle, mitotic cell cycle, M phase, DNA metabolic process, DNA replication, DNA repair, DNA recombination,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, response to DNA damage stimulus, cell cycle, meiosis, meiosis I, reciprocal meiotic recombination, intracellular signaling cascade,gamete generation, negative regulation of cell proliferation, phosphorylation, regulation of phosphate metabolic process, sexual reproduction, cell cycle process, cell cycle phase, DNA integrity checkpoint, multicellular organism reproduction, cellular response to stress, regulation of cell proliferation, regulation of phosphorylation, DNA damage response, signal transduction, regulation of kinase activity, regulation of protein kinase activity, reproductive process in a multicellular organism, regulation of phosphorus metabolic process, meiotic cell cycle, interphase, M phase of meiotic cell cycle, interphase of mitotic cell cycle, regulation of transferase activity, regulation of cell cycle,
细胞定位： Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). .
组织表达： Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon.
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